Effects of aqueous myrmecodia platytyrea extract on activity of brain acetylcholinesterase in swiss mice / Nurul Hafiza Mokhtar

• Main Author: Mokhtar, Nurul Hafiza
• Format: Thesis
• Language: English
• Published: 2013
• Subjects: Pharmacopoeias; Pharmacognosy. Pharmaceutical substances (Plant, animal, and inorganic)
• Online Access: https://ir.uitm.edu.my/id/eprint/109307/1/109307.PDF; https://ir.uitm.edu.my/id/eprint/109307/

Myrmecodia platytyrea is locally known as "pokok sarang semut". It is believed to have antioxidant properties. This research was conducted in order to check the potential of Myrmecodia platytyrea in reversing galactose-induced neurodegeneration. ln this research, over a treatment period of 21 days, mice were randomly divided into six groups ( each consists of 6 animals). They were given different types of treatments. Group 1 which acts as vehicle control were administered 0.9% normal saline subcutaneously, group 2 were administered 500 mg/kg of Myrmecodia Platytyrea per oral, group 3 were administered 0-galactose subcutaneously and 500 mg/kg of Myrmecodia Platytyrea per oral, group 4 which acts as negative control were administered 0-Galactose subcutaneously, group 5 which acts as positive control were administered vitamin C per oral and group 6 were administered 0- Galactose with vitamin C. After completing the treatment period, all of the mice were be sacrified, brain tissue collected and AChE test was done in order to check the AChE activity in all groups of mice. All the data were statistically analyzed by using turkey comparison tests. The results show that p> 0.05 between all groups of mice. This indicated that the levels of Acetylcholinesterase activity in all six groups of mice are not statistically different.