The effect of hibiscus rosa-sinensis leaves extract on MDA-MB-231 breast cancer cells / Nor Fatin Sharmira Abd Basir

• Main Author: Abd Basir, Nor Fatin Sharmira
• Format: Thesis
• Language: English
• Published: 2013
• Subjects: Pharmacognosy. Pharmaceutical substances (Plant, animal, and inorganic)
• Online Access: https://ir.uitm.edu.my/id/eprint/109195/1/109195.PDF; https://ir.uitm.edu.my/id/eprint/109195/

The purpose of this study was to know the effect of Hibiscus rosa sinensis leaves extract on MDA-MB-231 breast cancer cells. Four types of solvent extraction (methanol, ethyl acetate, acetone and petroleum ether) were used in this study. MTT assay showed that the extracts have the ability to reduce cancer cell viability in a dose dependence manner. The inhibition on 3T3, fibroblast cell lines also was observed and the inhibition percentage was slightly to be moderate and less toxic than MDA-MB-231 breast cancer cells. From the results, it has concluded that acetone extract of Hibiscus rosa sinensis leaves is the most potent in reducing the viability of MDA-MB-231 breast cancer cells. In conclusion, acetone extract of Hibiscus rosa sinensis leaves is a promising agent to be further investigated as a natural source for a novel anticancer agent.