Pharmaceutical properties and in­ vitro evaluation of ibuprofen-loaded PLGA nanoparticles by nanoprecipitation / Fatimah Tul Zahraa' Mahmud Pathi

• Main Author: Mahmud Pathi, Fatimah Tul Zahraa'
• Format: Thesis
• Language: English
• Published: 2009
• Subjects: Pharmaceutical industry; Pharmaceutical chemistry
• Online Access: https://ir.uitm.edu.my/id/eprint/107171/1/107171.PDF; https://ir.uitm.edu.my/id/eprint/107171/

The main objective of this study was to develop a polymeric drug delivery system for ibuprofen with final goal of improving the delivery of poor water soluble drugs. In order to achieve this goal, ibuprofen-loaded PLGA nanoparticles were prepared by the nanoprecipitation method. The following characteristics of nanoparticles formulate were determined; particle sizes, zeta potential, drug content, drug entrapment and drug release profile. Our result demonstrate that the methodology of preparation allowed the formation of nanometric ( <200 nm), a narrow size distribution ( polydispersity index< 0.2) and a negative surface charge (zeta potential values ranging from -27.4 to -31.3 m V). The release behaviour of ibuprofen from the developed nanoparticles exhibited a biphasic pattern characteristic by an initial fast release during the first 7 hours, followed by a slower and continues release. The formulation was optimised by 30% of theoretical drug loading with highest percentage of drug entrapment of 74.63% and drug content of 58.09%. The study has demonstrated that incorporation of ibuprofen in PLGA can improve drug release profile.