Dose responsive hormonal changes in female reproductive system of bisphenol A (BPA)-treated sprague­ dawley rats / Nurul Hiqma Ismail

• Main Author: Ismail, Nurul Hiqma
• Format: Thesis
• Language: English
• Published: 2009
• Subjects: Pharmaceutical industry; Pharmacognosy. Pharmaceutical substances (Plant, animal, and inorganic)
• Online Access: https://ir.uitm.edu.my/id/eprint/107033/1/107033.PDF; https://ir.uitm.edu.my/id/eprint/107033/

The demands towards BPA-based products keep on increasing each year higher, and this situation leads to much bigger exposure of BP A towards human and environmental. In the study, 28-days-old female SD rats were administered with BPA (50, 500, 1000 and 5000 µg/kg/day), ethinylestradiol and Tween 80 for 14 days and administration was done via force feeding. The plasma concentration of estriol (E3) and progesterone was quantified by ELISA. The plasma concentration of both hormones and mean difference of body weight (day-I to day-15) were analyzed using ANOVA with P value less than 0.05 was considered statistically significant. In conclusion, the study demonstrated that increased dose of BPA reduce the level of progesterone concentration. It was shown that different high doses of BPA resulted in inconsistency of plasma concentration of E3 and difference mean of body weight. The study also reported highest plasma progesterone concentration related to treatment with Tween 80, which suggests that Tween 80 may have effects on female reproductive hormones.