Histological changes in male reproductive systems of time responses bisphenol A treated sprague dawley rats / Bob Iskandar Kadir

• Main Author: Kadir, Bob Iskandar
• Format: Thesis
• Language: English
• Published: 2009
• Subjects: Pharmaceutical industry; Pharmaceutical chemistry
• Online Access: https://ir.uitm.edu.my/id/eprint/106324/1/106324.PDF; https://ir.uitm.edu.my/id/eprint/106324/

Bisphenol A (BPA) that is extensively used in food packaging industries is actually an estrogen-mimicking chemical that can bind to androgen receptors and inhibit the action of androgen. According to previous studies, BPA has been shown to have estrogenic activity and therefore, this study was designed to examine the time response effect of BPA on male reproductive system by using SD rats that had been exposed to BPA since juvenile age. BPA of lOOmg/kg body weight/ daily was forced-fed to SD rats for three different periods of 7 days, 14 days and 28 days. After each treatment, all the treated rats were sacrificed and the testes were removed and processed for histological analysis. The obtained result showed some histological changes in seminiferous tubules of testes in adult rats, such as loss of luminal space of the seminiferous tubules, accumulation of amorphous material in the tubes, reduction in the number of maturating spermatids and aberrant distribution of spermatogenic cells within the epithelium. In conclusion, the result obtained indicates that exposure or consumption of BPA since juvenile age might has profound effects on the tissue arrangement in testes as well as on the spermatogenesis.