Elucidation of molecular processes during solubility enhancement of aqueous insoluble drug by NMR spectroscopy / Lisma Hijriani Aris

• Main Author: Aris, Lisma Hijriani
• Format: Thesis
• Language: English
• Published: 2009
• Subjects: Pharmaceutical industry; Pharmacopoeias; Pharmaceutical dosage forms
• Online Access: https://ir.uitm.edu.my/id/eprint/106316/1/106316.PDF; https://ir.uitm.edu.my/id/eprint/106316/

13-cyclodextrin is one type of cylodextrins that has six dextrose rings and has the ability to act as a hydrotropic agent. It has the ability to bind to organic molecules in aqueous solution which may result in solubility enhancement of the guest molecule. An inclusion between Griseofulvin, an antifungal drug which has a poor solubility in aqueous solution with 13-cyclodextrin was obtained. The inclusion complex was then investigated by means of 1H NMR spectroscopy in aqueous solution. NMR spectroscopy is the most reliable method for the study of inclusion complex interactions as both the host and guest molecules can be observed simultaneously.