Influence of gender and diabetes on antioxidant enzyme levels in the aorta of WKY rats / Noraihan Abd Karim

• Main Author: Abd Karim, Noraihan
• Format: Thesis
• Language: English
• Published: 2009
• Subjects: Pharmaceutical industry; Pharmacognosy. Pharmaceutical substances (Plant, animal, and inorganic)
• Online Access: https://ir.uitm.edu.my/id/eprint/105851/1/105851.PDF; https://ir.uitm.edu.my/id/eprint/105851/

In present study, the gender differences in activities of key antioxidant in normoglycemic and diabetic rats were examined. SOD activities were significantly higher in normoglycemic female compared to male rats, while lower SOD activity was observed in diabetic female compared to male rats. Catalase activity was higher in normoglycemic female rats, as well as in diabetic female compared to male rats, which may be due to higher production of hydrogen peroxide in the former. These results suggest that diabetes reduces levels of SOD and removes the gender differences in levels of these enzymes in both genders.