Preparation and evaluation of the surface properties of griseofulvin solid dispersions with three different saccharides / Kamal Rasyid Samsudin

• Main Author: Samsudin, Kamal Rasyid
• Format: Thesis
• Language: English
• Published: 2009
• Subjects: Pharmaceutical industry; Pharmaceutical chemistry
• Online Access: https://ir.uitm.edu.my/id/eprint/105529/1/105529.PDF; https://ir.uitm.edu.my/id/eprint/105529/

The present study proposed griseofulvin as drug candidate because of its aqueous in solubility, where it foresees to study contact angle extensively as a parameter and to establish how different saccharides such as lactose, com starch and potato starch incorporate hydrophilicity to a hydrophobic drug so to enhance its solubility. The effects of contact angle on the mixture of griseofulvin with saccharides were investigated by using sessile drop method. The pellets containing the mixture of griseofulvin and saccharides were measured at ratio (1:1, 1:2, 1:3, 1:4, 1:5, 1:6, 1:7, 1:8) by weight. For griseofulvin alone, the contact angle was observed to be very high, 65.58°, supporting the fact that the drug is very hydrophobic. Upon incorporation of lactose, com starch and potato starch, the contact angle was decreased with different extent of intensity corresponding to the different saccharides respectively. Upon comparison, presence of com starch significantly improved the wettability of griseofulvin as it reduces the contact angle to the highest extent among the three, suggesting it can better incorporate hydrophilic property than that of the other two saccharides. On the basis of this study, an extensive data on contact angle have been gathered, however, these findings have to be further validated with other related experimental findings.