Structure-based drug modeling of curcuma longa as alternative drug for breast cancer / Maryam Jamilah Laharadi @ Lahuri

• Main Author: Laharadi @ Lahuri, Maryam Jamilah
• Format: Thesis
• Language: English
• Published: 2009
• Subjects: Pharmaceutical industry; Pharmaceutical dosage forms; Pharmaceutical chemistry
• Online Access: https://ir.uitm.edu.my/id/eprint/105244/1/105244.PDF; https://ir.uitm.edu.my/id/eprint/105244/

Overexpression of epidermal growth factor (EGFR) tyrosine kinase was related to occurance, lymph metastasis and pathologic types of breast cancer. lnhibition of the EGFR tyrosine kinase activity by small molecules has proved effective for the treatment of breast cancer. Study has been done before where the crystal structure of EGFR has been used to identify inhibitor chemotypes by docking-based in silico screening of a large virtual chemical library followed up by experimental validation. Several compounds have been identified since then and one of them is Lapatinib which interact with EGFR coded in Protein Data Bank (PDB) as 1 xkk receptor. We analyzed the compound presence in Curcuma longa and identify the one that can give more or less similar effects such as Lapatinib through in silico models.