Time response study of bisphenol A (BPA) towards the induction of oxidative stress in the brain of sprague dawley female rats / Norfazihan Mohd Marzuki

• Main Author: Mohd Marzuki, Norfazihan
• Format: Thesis
• Language: English
• Published: 2009
• Subjects: Pharmacognosy. Pharmaceutical substances (Plant, animal, and inorganic); Pharmaceutical chemistry
• Online Access: https://ir.uitm.edu.my/id/eprint/105212/1/105212.PDF; https://ir.uitm.edu.my/id/eprint/105212/

Bisphenol A (BPA) or 2,2-bis-(4-hydroxyphenil)propane is a monomer used in the production of its polymers which are polycarbonate plastics and epoxy resins. It is an organic compound which is extensively used as daily consumer products also has been found widespread in the environment. It is also known as one of the most ubiquotous environmental endocrine disruptor compound. Without realizing about the danger that it brings along, BP A is frequently ingested or absorbed by humans and pass through into the body. The study focused on the duration of BPA towards the induction of oxidative stress in the rat's brain. Oxidative stress is when the oxidants in the body are more intense compared to the antioxidants, then lead to cell damage. Antioxidants for example glutathione peroxidase (GPx) are the compound that responsible for defense against oxidants. BP A can induce oxidative stress in the brain by altering the properties of oxidants and also antioxidants. BP A administration did alter the body weight of female SD rats and impaired the development of the brain in longer duration of exposure. BP A also decreased the GPx activity and overall antioxidant concentration in the brain of female SD rats.