Synthesis of stilbenoids via heck reaction in ionic liquid accelerated by microwave irradiation / Noor Azimah Abdullah

Ionic liquids, being composed entirely of ions have interesting characteristics that make them suitable to be used as solvents for Heck reaction. This study was carried out to investigate the effects of ionic liquids and microwave irradiation on Heck reaction. 4- iodoanisole and 4-iodophenylbenzyl e...

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Main Author: Abdullah, Noor Azimah
Format: Thesis
Language:English
Published: 2008
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Online Access:https://ir.uitm.edu.my/id/eprint/101093/1/101093.PDF
https://ir.uitm.edu.my/id/eprint/101093/
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spelling my.uitm.ir.1010932024-09-28T23:18:30Z https://ir.uitm.edu.my/id/eprint/101093/ Synthesis of stilbenoids via heck reaction in ionic liquid accelerated by microwave irradiation / Noor Azimah Abdullah Abdullah, Noor Azimah Pharmaceutical chemistry Ionic liquids, being composed entirely of ions have interesting characteristics that make them suitable to be used as solvents for Heck reaction. This study was carried out to investigate the effects of ionic liquids and microwave irradiation on Heck reaction. 4- iodoanisole and 4-iodophenylbenzyl ether were used as the aryl halide, and 4- methoxystyrene as the alkene. Six different reaction conditions were used in order to synthesize stilbenes via palladium-catalyzed Heck reactions. The coupling of 4- iodoanisole and 4-methoxystyrene were done for six hours in ionic liquids bmimPF and bmimlsf'a. The yields obtained were 43.69% and 24.27% respectively. The coupling between 4-iodophenylbenzyl ether and 4-methoxystyrene gave the yield of 49.02%. Heck reaction between 4-iodoanisole and 4-methoxystyrene in ionic liquid bmimBF4, accelerated by microwave irradiation produced as much as 67.96% stilbene in less than two hours. The results showed that the reaction time could be shortened to just several hours to produce the stilbene as compared to the reaction in conventional solvents such as DMF that normally takes between one to three days. 2008 Thesis NonPeerReviewed text en https://ir.uitm.edu.my/id/eprint/101093/1/101093.PDF Synthesis of stilbenoids via heck reaction in ionic liquid accelerated by microwave irradiation / Noor Azimah Abdullah. (2008) Degree thesis, thesis, Universiti Teknologi MARA (Kampus Puncak Alam).
institution Universiti Teknologi Mara
building Tun Abdul Razak Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Teknologi Mara
content_source UiTM Institutional Repository
url_provider http://ir.uitm.edu.my/
language English
topic Pharmaceutical chemistry
spellingShingle Pharmaceutical chemistry
Abdullah, Noor Azimah
Synthesis of stilbenoids via heck reaction in ionic liquid accelerated by microwave irradiation / Noor Azimah Abdullah
description Ionic liquids, being composed entirely of ions have interesting characteristics that make them suitable to be used as solvents for Heck reaction. This study was carried out to investigate the effects of ionic liquids and microwave irradiation on Heck reaction. 4- iodoanisole and 4-iodophenylbenzyl ether were used as the aryl halide, and 4- methoxystyrene as the alkene. Six different reaction conditions were used in order to synthesize stilbenes via palladium-catalyzed Heck reactions. The coupling of 4- iodoanisole and 4-methoxystyrene were done for six hours in ionic liquids bmimPF and bmimlsf'a. The yields obtained were 43.69% and 24.27% respectively. The coupling between 4-iodophenylbenzyl ether and 4-methoxystyrene gave the yield of 49.02%. Heck reaction between 4-iodoanisole and 4-methoxystyrene in ionic liquid bmimBF4, accelerated by microwave irradiation produced as much as 67.96% stilbene in less than two hours. The results showed that the reaction time could be shortened to just several hours to produce the stilbene as compared to the reaction in conventional solvents such as DMF that normally takes between one to three days.
format Thesis
author Abdullah, Noor Azimah
author_facet Abdullah, Noor Azimah
author_sort Abdullah, Noor Azimah
title Synthesis of stilbenoids via heck reaction in ionic liquid accelerated by microwave irradiation / Noor Azimah Abdullah
title_short Synthesis of stilbenoids via heck reaction in ionic liquid accelerated by microwave irradiation / Noor Azimah Abdullah
title_full Synthesis of stilbenoids via heck reaction in ionic liquid accelerated by microwave irradiation / Noor Azimah Abdullah
title_fullStr Synthesis of stilbenoids via heck reaction in ionic liquid accelerated by microwave irradiation / Noor Azimah Abdullah
title_full_unstemmed Synthesis of stilbenoids via heck reaction in ionic liquid accelerated by microwave irradiation / Noor Azimah Abdullah
title_sort synthesis of stilbenoids via heck reaction in ionic liquid accelerated by microwave irradiation / noor azimah abdullah
publishDate 2008
url https://ir.uitm.edu.my/id/eprint/101093/1/101093.PDF
https://ir.uitm.edu.my/id/eprint/101093/
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score 13.2014675