Synthetic B-Cell epitopes eliciting cross-neutralizing antibodies: Strategies for future dengue vaccine

• Main Authors: Ramanathan, Babu *, Poh, Chit Laa *, Kirk, Kristin, McBride, William John Hannan, Aaskov, John, Grollo, Lara
• Format: Article
• Language: English
• Published: PLOS 2016
• Subjects: QR Microbiology; R Medicine (General)
• Online Access: http://eprints.sunway.edu.my/454/1/Ramanathan%202016%20Synthetic%20B.pdf; http://eprints.sunway.edu.my/454/; http://dx.doi.org/10.1371/journal.pone.0155900

Dengue virus (DENV) is a major public health threat worldwide. A key element in protection from dengue fever is the neutralising antibody response. Anti-dengue IgG purified from DENV-2 infected human sera showed reactivity against several peptides when evaluated by ELISA and epitope extraction techn...