Candida glabrata infection of a pancreatic pseudocyst in a COVID-19 patient: A case report and review of the literature
Introduction Pancreatic pseudocysts remain a feared complication of acute or chronic pancreatitis and are often characterized by collections of fluids due to underlying damage to the pancreatic ducts, culminating in a walled-off region bereft of an epithelial layer but surrounded by granulation tis...
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my.sunway.eprints.31372024-08-14T04:29:58Z http://eprints.sunway.edu.my/3137/ Candida glabrata infection of a pancreatic pseudocyst in a COVID-19 patient: A case report and review of the literature Khan, Mohammad Aasim Almas, Talal Ullah, Muneeb Alkhattab, Maha Shaikh, Fathema Shaikh, Sufyan Bagwe, Isha Antony, Meetty Khedro, Tarek Nagarajan, Vikneswaran Raj Ramjohn, Joshua Alsufyani, Reema Almubarak, Dana Al-Awaid,, Abdulla Hussain Alsufyani, Majid Khan, Muhammad Omer Huang, Helen Oruk, Mert Samy, Arjun Alqallaf, Nagi Shafi, Adil Adeel, Aqsa Khan, Muhammad Kashif Nagarajan, Dhineswaran Raj * QP Physiology RC Internal medicine Introduction Pancreatic pseudocysts remain a feared complication of acute or chronic pancreatitis and are often characterized by collections of fluids due to underlying damage to the pancreatic ducts, culminating in a walled-off region bereft of an epithelial layer but surrounded by granulation tissue. While fungal infections of pancreatic pseudocysts are rarely encountered, candida albicans remains the most frequently implicated organism. Case presentation A 55-year-old male presented with pain in the left-hypochondriac region, accompanied by non-bilious emesis and nausea. Interestingly, the patient also tested positive for a COVID-19 infection. Investigative workup divulged enhancing pancreatic walls with a radiologic impression consistent with a pancreatic pseudocyst. An ultrasound-guided external drainage was performed; the drainage was conducted unremarkably, with the resultant fluid collection revealing the presence of Candida Glabrata. The patient was commenced on antifungal therapy and continues to do well to date. Discussion Infectious ailments of pancreatic pseudocysts remain a widely known complication of acute pancreatitis. While it is rare, fungal infection is a crucial consideration for patients with pancreatic pseudocysts, especially in the context of a lack of an adequate response to antibiotics, deterioration, comorbidities, and immunocompromised states. Conclusion Rapid identification of the microbe responsible for pancreatic pseudocyst infection is vital for time-sensitive treatment and a more rapid recovery, curbing associated morbidity and mortality. Lippincott Williams & Wilkins 2022 Article PeerReviewed Khan, Mohammad Aasim and Almas, Talal and Ullah, Muneeb and Alkhattab, Maha and Shaikh, Fathema and Shaikh, Sufyan and Bagwe, Isha and Antony, Meetty and Khedro, Tarek and Nagarajan, Vikneswaran Raj and Ramjohn, Joshua and Alsufyani, Reema and Almubarak, Dana and Al-Awaid,, Abdulla Hussain and Alsufyani, Majid and Khan, Muhammad Omer and Huang, Helen and Oruk, Mert and Samy, Arjun and Alqallaf, Nagi and Shafi, Adil and Adeel, Aqsa and Khan, Muhammad Kashif and Nagarajan, Dhineswaran Raj * (2022) Candida glabrata infection of a pancreatic pseudocyst in a COVID-19 patient: A case report and review of the literature. Annals of Medicine & Surgery, 77. pp. 1-6. ISSN 2049-0801 https://journals.lww.com/annals-of-medicine-and-surgery/fulltext/2022/05000/candida_glabrata_infection_of_a_pancreatic.95.aspx 10.1016/j.amsu.2022.103648 |
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QP Physiology RC Internal medicine Khan, Mohammad Aasim Almas, Talal Ullah, Muneeb Alkhattab, Maha Shaikh, Fathema Shaikh, Sufyan Bagwe, Isha Antony, Meetty Khedro, Tarek Nagarajan, Vikneswaran Raj Ramjohn, Joshua Alsufyani, Reema Almubarak, Dana Al-Awaid,, Abdulla Hussain Alsufyani, Majid Khan, Muhammad Omer Huang, Helen Oruk, Mert Samy, Arjun Alqallaf, Nagi Shafi, Adil Adeel, Aqsa Khan, Muhammad Kashif Nagarajan, Dhineswaran Raj * Candida glabrata infection of a pancreatic pseudocyst in a COVID-19 patient: A case report and review of the literature |
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Introduction
Pancreatic pseudocysts remain a feared complication of acute or chronic pancreatitis and are often characterized by collections of fluids due to underlying damage to the pancreatic ducts, culminating in a walled-off region bereft of an epithelial layer but surrounded by granulation tissue. While fungal infections of pancreatic pseudocysts are rarely encountered, candida albicans remains the most frequently implicated organism.
Case presentation
A 55-year-old male presented with pain in the left-hypochondriac region, accompanied by non-bilious emesis and nausea. Interestingly, the patient also tested positive for a COVID-19 infection. Investigative workup divulged enhancing pancreatic walls with a radiologic impression consistent with a pancreatic pseudocyst. An ultrasound-guided external drainage was performed; the drainage was conducted unremarkably, with the resultant fluid collection revealing the presence of Candida Glabrata. The patient was commenced on antifungal therapy and continues to do well to date.
Discussion
Infectious ailments of pancreatic pseudocysts remain a widely known complication of acute pancreatitis. While it is rare, fungal infection is a crucial consideration for patients with pancreatic pseudocysts, especially in the context of a lack of an adequate response to antibiotics, deterioration, comorbidities, and immunocompromised states.
Conclusion
Rapid identification of the microbe responsible for pancreatic pseudocyst infection is vital for time-sensitive treatment and a more rapid recovery, curbing associated morbidity and mortality. |
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Khan, Mohammad Aasim Almas, Talal Ullah, Muneeb Alkhattab, Maha Shaikh, Fathema Shaikh, Sufyan Bagwe, Isha Antony, Meetty Khedro, Tarek Nagarajan, Vikneswaran Raj Ramjohn, Joshua Alsufyani, Reema Almubarak, Dana Al-Awaid,, Abdulla Hussain Alsufyani, Majid Khan, Muhammad Omer Huang, Helen Oruk, Mert Samy, Arjun Alqallaf, Nagi Shafi, Adil Adeel, Aqsa Khan, Muhammad Kashif Nagarajan, Dhineswaran Raj * |
author_facet |
Khan, Mohammad Aasim Almas, Talal Ullah, Muneeb Alkhattab, Maha Shaikh, Fathema Shaikh, Sufyan Bagwe, Isha Antony, Meetty Khedro, Tarek Nagarajan, Vikneswaran Raj Ramjohn, Joshua Alsufyani, Reema Almubarak, Dana Al-Awaid,, Abdulla Hussain Alsufyani, Majid Khan, Muhammad Omer Huang, Helen Oruk, Mert Samy, Arjun Alqallaf, Nagi Shafi, Adil Adeel, Aqsa Khan, Muhammad Kashif Nagarajan, Dhineswaran Raj * |
author_sort |
Khan, Mohammad Aasim |
title |
Candida glabrata infection of a pancreatic pseudocyst in a COVID-19 patient: A case report and review of the literature |
title_short |
Candida glabrata infection of a pancreatic pseudocyst in a COVID-19 patient: A case report and review of the literature |
title_full |
Candida glabrata infection of a pancreatic pseudocyst in a COVID-19 patient: A case report and review of the literature |
title_fullStr |
Candida glabrata infection of a pancreatic pseudocyst in a COVID-19 patient: A case report and review of the literature |
title_full_unstemmed |
Candida glabrata infection of a pancreatic pseudocyst in a COVID-19 patient: A case report and review of the literature |
title_sort |
candida glabrata infection of a pancreatic pseudocyst in a covid-19 patient: a case report and review of the literature |
publisher |
Lippincott Williams & Wilkins |
publishDate |
2022 |
url |
http://eprints.sunway.edu.my/3137/ https://journals.lww.com/annals-of-medicine-and-surgery/fulltext/2022/05000/candida_glabrata_infection_of_a_pancreatic.95.aspx |
_version_ |
1808975647517704192 |
score |
13.19449 |