Epidemiology, clinical ramifications, and cellular pathogenesis of COVID-19 mRNA-vaccination-induced adverse cardiovascular outcomes: A state-of-the-heart review
The coronavirus disease 2019 (COVID-19) has overwhelming healthcare systems globally. To date, a myriad of therapeutic regimens has been employed in an attempt to curb the ramifications of a severe COVID-19 infection. Amidst the ongoing pandemic, the advent and efficacious uptake of COVID-19 vaccina...
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my.sunway.eprints.31302024-08-13T23:44:53Z http://eprints.sunway.edu.my/3130/ Epidemiology, clinical ramifications, and cellular pathogenesis of COVID-19 mRNA-vaccination-induced adverse cardiovascular outcomes: A state-of-the-heart review Almas, Talal Rehman, Sarah Mansour, Eyad Khedro, Tarek Alansari, Ali Jahanzeb, Malik * Alshareef, Norah Nagarajan, Vikneswaran Raj Al-Awaid, Abdulla Hussain Alsufyani, Reema Alsufyani, Majid Rifai, Ali Ahlam, Alzahrani Dhineswaran, Raj Nagarajan * Abdullatif, Tala Gunasaegaram, Varman Alzadjali, Enaam Subramanian, Arthi Rahman, Abida Sattar, Yasar Galo, Jason Virk, Hafeez Ul Hassan Alraies, M. Chadi RA Public aspects of medicine RC Internal medicine The coronavirus disease 2019 (COVID-19) has overwhelming healthcare systems globally. To date, a myriad of therapeutic regimens has been employed in an attempt to curb the ramifications of a severe COVID-19 infection. Amidst the ongoing pandemic, the advent and efficacious uptake of COVID-19 vaccination has significantly reduced disease-related hospitalizations and mortality. Nevertheless, many side-effects are being reported after COVID-19 vaccinations and myocarditis is the most commonly reported sequelae post vaccination. Majority of these diseases are associated with COVID-19 mRNA vaccines. Various studies have established a temporal relationship between these complications, yet the causality and the underlying pathogenesis remain hypothetical. In this review, we aim to critically appraise the available literature regarding the cardiovascular side effects of the various mRNA vaccines and the associated pathophysiology. Elsevier 2022 Article PeerReviewed Almas, Talal and Rehman, Sarah and Mansour, Eyad and Khedro, Tarek and Alansari, Ali and Jahanzeb, Malik * and Alshareef, Norah and Nagarajan, Vikneswaran Raj and Al-Awaid, Abdulla Hussain and Alsufyani, Reema and Alsufyani, Majid and Rifai, Ali and Ahlam, Alzahrani and Dhineswaran, Raj Nagarajan * and Abdullatif, Tala and Gunasaegaram, Varman and Alzadjali, Enaam and Subramanian, Arthi and Rahman, Abida and Sattar, Yasar and Galo, Jason and Virk, Hafeez Ul Hassan and Alraies, M. Chadi (2022) Epidemiology, clinical ramifications, and cellular pathogenesis of COVID-19 mRNA-vaccination-induced adverse cardiovascular outcomes: A state-of-the-heart review. Biomedicine and Pharmacotherapy, 149. ISSN 0753-3322 https://doi.org/10.1016/j.biopha.2022.112843 10.1016/j.biopha.2022.112843 |
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RA Public aspects of medicine RC Internal medicine Almas, Talal Rehman, Sarah Mansour, Eyad Khedro, Tarek Alansari, Ali Jahanzeb, Malik * Alshareef, Norah Nagarajan, Vikneswaran Raj Al-Awaid, Abdulla Hussain Alsufyani, Reema Alsufyani, Majid Rifai, Ali Ahlam, Alzahrani Dhineswaran, Raj Nagarajan * Abdullatif, Tala Gunasaegaram, Varman Alzadjali, Enaam Subramanian, Arthi Rahman, Abida Sattar, Yasar Galo, Jason Virk, Hafeez Ul Hassan Alraies, M. Chadi Epidemiology, clinical ramifications, and cellular pathogenesis of COVID-19 mRNA-vaccination-induced adverse cardiovascular outcomes: A state-of-the-heart review |
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The coronavirus disease 2019 (COVID-19) has overwhelming healthcare systems globally. To date, a myriad of therapeutic regimens has been employed in an attempt to curb the ramifications of a severe COVID-19 infection. Amidst the ongoing pandemic, the advent and efficacious uptake of COVID-19 vaccination has significantly reduced disease-related hospitalizations and mortality. Nevertheless, many side-effects are being reported after COVID-19 vaccinations and myocarditis is the most commonly reported sequelae post vaccination. Majority of these diseases are associated with COVID-19 mRNA vaccines. Various studies have established a temporal relationship between these complications, yet the causality and the underlying pathogenesis remain hypothetical. In this review, we aim to critically appraise the available literature regarding the cardiovascular side effects of the various mRNA vaccines and the associated pathophysiology. |
format |
Article |
author |
Almas, Talal Rehman, Sarah Mansour, Eyad Khedro, Tarek Alansari, Ali Jahanzeb, Malik * Alshareef, Norah Nagarajan, Vikneswaran Raj Al-Awaid, Abdulla Hussain Alsufyani, Reema Alsufyani, Majid Rifai, Ali Ahlam, Alzahrani Dhineswaran, Raj Nagarajan * Abdullatif, Tala Gunasaegaram, Varman Alzadjali, Enaam Subramanian, Arthi Rahman, Abida Sattar, Yasar Galo, Jason Virk, Hafeez Ul Hassan Alraies, M. Chadi |
author_facet |
Almas, Talal Rehman, Sarah Mansour, Eyad Khedro, Tarek Alansari, Ali Jahanzeb, Malik * Alshareef, Norah Nagarajan, Vikneswaran Raj Al-Awaid, Abdulla Hussain Alsufyani, Reema Alsufyani, Majid Rifai, Ali Ahlam, Alzahrani Dhineswaran, Raj Nagarajan * Abdullatif, Tala Gunasaegaram, Varman Alzadjali, Enaam Subramanian, Arthi Rahman, Abida Sattar, Yasar Galo, Jason Virk, Hafeez Ul Hassan Alraies, M. Chadi |
author_sort |
Almas, Talal |
title |
Epidemiology, clinical ramifications, and cellular pathogenesis of COVID-19 mRNA-vaccination-induced adverse cardiovascular outcomes: A state-of-the-heart review |
title_short |
Epidemiology, clinical ramifications, and cellular pathogenesis of COVID-19 mRNA-vaccination-induced adverse cardiovascular outcomes: A state-of-the-heart review |
title_full |
Epidemiology, clinical ramifications, and cellular pathogenesis of COVID-19 mRNA-vaccination-induced adverse cardiovascular outcomes: A state-of-the-heart review |
title_fullStr |
Epidemiology, clinical ramifications, and cellular pathogenesis of COVID-19 mRNA-vaccination-induced adverse cardiovascular outcomes: A state-of-the-heart review |
title_full_unstemmed |
Epidemiology, clinical ramifications, and cellular pathogenesis of COVID-19 mRNA-vaccination-induced adverse cardiovascular outcomes: A state-of-the-heart review |
title_sort |
epidemiology, clinical ramifications, and cellular pathogenesis of covid-19 mrna-vaccination-induced adverse cardiovascular outcomes: a state-of-the-heart review |
publisher |
Elsevier |
publishDate |
2022 |
url |
http://eprints.sunway.edu.my/3130/ https://doi.org/10.1016/j.biopha.2022.112843 |
_version_ |
1808975646353784832 |
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13.19449 |