Potential anti-acanthamoebic effects through inhibition of CYP51 by novel quinazolinones

• Main Authors: Usman, Ahmed *, Ho, Keat Yie, Simon, Samson Eugin *, Saad, Syed Muhammad, Ong, Seng Kai *, Areeba, Anwar, Tan, Kuan Onn *, Nanthini, Sridewi, Khan, Khalid Mohammed, Khan, Naveed Ahmed, Ayaz, Anwar *
• Format: Article
• Published: Elsevier 2022
• Subjects: QL Zoology; RM Therapeutics. Pharmacology
• Online Access: http://eprints.sunway.edu.my/3115/; https://doi.org/10.1016/j.actatropica.2022.106440

Acanthamoeba spp. are free living amoebae which can give rise to Acanthamoeba keratitis and granulomatous amoebic encephalitis. The surface of Acanthamoeba contains ergosterol which is an important target for drug development against eukaryotic microorganisms. A library of ten functionally diverse q...