Molecular Regulatory Roles of Long Non-coding RNA HOTTIP: An Overview in Gastrointestinal Cancers
Gastrointestinal (GI) cancers presented an alarmingly high number of new cancer cases worldwide and are highly characterised by poor prognosis. The poor overall survival is mainly due to late detection and emerging challenges in treatment, particularly chemoresistance. Thus, the identification of no...
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my.sunway.eprints.31122024-08-13T05:49:00Z http://eprints.sunway.edu.my/3112/ Molecular Regulatory Roles of Long Non-coding RNA HOTTIP: An Overview in Gastrointestinal Cancers Ummi Zulaiqha, Hamid Sim, Maw Shin Rhanye, Mac Guad Vetriselvan, Subramaniyan Mahendran, Sekar Fuloria, Neeraj Kumar Fuloria, Shivkanya Choy, Ker Woon Ismail, Muhammad Fareez Srinivasa Reddy, Bonam Wu, Yuan Seng * QP Physiology RC Internal medicine Gastrointestinal (GI) cancers presented an alarmingly high number of new cancer cases worldwide and are highly characterised by poor prognosis. The poor overall survival is mainly due to late detection and emerging challenges in treatment, particularly chemoresistance. Thus, the identification of novel molecular targets in GI cancer is highly regarded as the main focus. Recently, long non-coding RNAs (lncRNAs) have been discovered as potential novel molecular targets for combating cancer, as they are highly associated with carcinogenesis and have a great impact on cancer progression. Amongst lncRNAs, HOTTIP has demonstrated a prominent oncogenic regulation in cancer progression, particularly in GI cancers, including oesophageal cancer, gastric cancer, hepatocellular carcinoma, pancreatic cancer, and colorectal cancer. This review aimed to present a focused update on the regulatory roles of HOTTIP in GI cancer progression and chemoresistance, as well as deciphering the associated molecular mechanisms underlying their impact on cancer phenotypes and chemoresistance and the key molecules involved. It has been reported that it regulates the expression of various genes and proteins in GI cancers that impact cellular functions, including proliferation, adhesion, migration and invasion, apoptosis, chemosensitivity, and tumour differentiation. Furthermore, HOTTIP was also discovered to have a higher diagnostic value as compared to existing diagnostic biomarkers. Overall, HOTTIP has presented itself as a novel therapeutic target and potential diagnostic biomarker in the development of GI cancer treatment. Bentham Science Publishers 2022 Article PeerReviewed Ummi Zulaiqha, Hamid and Sim, Maw Shin and Rhanye, Mac Guad and Vetriselvan, Subramaniyan and Mahendran, Sekar and Fuloria, Neeraj Kumar and Fuloria, Shivkanya and Choy, Ker Woon and Ismail, Muhammad Fareez and Srinivasa Reddy, Bonam and Wu, Yuan Seng * (2022) Molecular Regulatory Roles of Long Non-coding RNA HOTTIP: An Overview in Gastrointestinal Cancers. Current Molecular Medicine, 22 (6). pp. 478-490. ISSN 1875-5666 https://www.eurekaselect.com/article/117162 10.2174/1566524021666210806162848 Full text linksCite |
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QP Physiology RC Internal medicine Ummi Zulaiqha, Hamid Sim, Maw Shin Rhanye, Mac Guad Vetriselvan, Subramaniyan Mahendran, Sekar Fuloria, Neeraj Kumar Fuloria, Shivkanya Choy, Ker Woon Ismail, Muhammad Fareez Srinivasa Reddy, Bonam Wu, Yuan Seng * Molecular Regulatory Roles of Long Non-coding RNA HOTTIP: An Overview in Gastrointestinal Cancers |
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Gastrointestinal (GI) cancers presented an alarmingly high number of new cancer cases worldwide and are highly characterised by poor prognosis. The poor overall survival is mainly due to late detection and emerging challenges in treatment, particularly chemoresistance. Thus, the identification of novel molecular targets in GI cancer is highly regarded as the main focus. Recently, long non-coding RNAs (lncRNAs) have been discovered as potential novel molecular targets for combating cancer, as they are highly associated with carcinogenesis and have a great impact on cancer progression. Amongst lncRNAs, HOTTIP has demonstrated a prominent oncogenic regulation in cancer progression, particularly in GI cancers, including oesophageal cancer, gastric cancer, hepatocellular carcinoma, pancreatic cancer, and colorectal cancer. This review aimed to present a focused update on the regulatory roles of HOTTIP in GI cancer progression and chemoresistance, as well as deciphering the associated molecular mechanisms underlying their impact on cancer phenotypes and chemoresistance and the key molecules involved. It has been reported that it regulates the expression of various genes and proteins in GI cancers that impact cellular functions, including proliferation, adhesion, migration and invasion, apoptosis, chemosensitivity, and tumour differentiation. Furthermore, HOTTIP was also discovered to have a higher diagnostic value as compared to existing diagnostic biomarkers. Overall, HOTTIP has presented itself as a novel therapeutic target and potential diagnostic biomarker in the development of GI cancer treatment. |
format |
Article |
author |
Ummi Zulaiqha, Hamid Sim, Maw Shin Rhanye, Mac Guad Vetriselvan, Subramaniyan Mahendran, Sekar Fuloria, Neeraj Kumar Fuloria, Shivkanya Choy, Ker Woon Ismail, Muhammad Fareez Srinivasa Reddy, Bonam Wu, Yuan Seng * |
author_facet |
Ummi Zulaiqha, Hamid Sim, Maw Shin Rhanye, Mac Guad Vetriselvan, Subramaniyan Mahendran, Sekar Fuloria, Neeraj Kumar Fuloria, Shivkanya Choy, Ker Woon Ismail, Muhammad Fareez Srinivasa Reddy, Bonam Wu, Yuan Seng * |
author_sort |
Ummi Zulaiqha, Hamid |
title |
Molecular Regulatory Roles of Long Non-coding RNA HOTTIP: An Overview in Gastrointestinal Cancers |
title_short |
Molecular Regulatory Roles of Long Non-coding RNA HOTTIP: An Overview in Gastrointestinal Cancers |
title_full |
Molecular Regulatory Roles of Long Non-coding RNA HOTTIP: An Overview in Gastrointestinal Cancers |
title_fullStr |
Molecular Regulatory Roles of Long Non-coding RNA HOTTIP: An Overview in Gastrointestinal Cancers |
title_full_unstemmed |
Molecular Regulatory Roles of Long Non-coding RNA HOTTIP: An Overview in Gastrointestinal Cancers |
title_sort |
molecular regulatory roles of long non-coding rna hottip: an overview in gastrointestinal cancers |
publisher |
Bentham Science Publishers |
publishDate |
2022 |
url |
http://eprints.sunway.edu.my/3112/ https://www.eurekaselect.com/article/117162 |
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1808975643506900992 |
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13.19449 |