Aristolochic acid-associated cancers: a public health risk in need of global action

Aristolochic acids (AAs) are a group of naturally occurring compounds present in many plant species of the Aristolochiaceae family. Exposure to AA is a significant risk factor for severe nephropathy, and urological and hepatobiliary cancers (among others) that are often recurrent and characterized b...

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Main Authors: Das, Samrat, Thakur, Shefali, Korenjak, Michael, Sidorenko, Viktoriya S, Chung, Felicia Fei Lei *, Zavadil, Jiri
Format: Article
Published: Nature Research 2022
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Online Access:http://eprints.sunway.edu.my/3081/
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spelling my.sunway.eprints.30812024-08-12T09:09:12Z http://eprints.sunway.edu.my/3081/ Aristolochic acid-associated cancers: a public health risk in need of global action Das, Samrat Thakur, Shefali Korenjak, Michael Sidorenko, Viktoriya S Chung, Felicia Fei Lei * Zavadil, Jiri QK Botany RC Internal medicine Aristolochic acids (AAs) are a group of naturally occurring compounds present in many plant species of the Aristolochiaceae family. Exposure to AA is a significant risk factor for severe nephropathy, and urological and hepatobiliary cancers (among others) that are often recurrent and characterized by the prominent mutational fingerprint of AA. However, herbal medicinal products that contain AA continue to be manufactured and marketed worldwide with inadequate regulation, and possible environmental exposure routes receive little attention. As the trade of food and dietary supplements becomes increasingly globalized, we propose that further inaction on curtailing AA exposure will have far-reaching negative effects on the disease trends of AA-associated cancers. Our Review aims to systematically present the historical and current evidence for the mutagenicity and carcinogenicity of AA, and the effect of removing sources of AA exposure on cancer incidence trends. We discuss the persisting challenges of assessing the scale of AA-related carcinogenicity, and the obstacles that must be overcome in curbing AA exposure and preventing associated cancers. Overall, this Review aims to strengthen the case for the implementation of prevention measures against AA's multifaceted, detrimental and potentially fully preventable effects on human cancer development. Nature Research 2022 Article PeerReviewed Das, Samrat and Thakur, Shefali and Korenjak, Michael and Sidorenko, Viktoriya S and Chung, Felicia Fei Lei * and Zavadil, Jiri (2022) Aristolochic acid-associated cancers: a public health risk in need of global action. Nature Reviews Cancer, 22. pp. 576-591. ISSN 1474-1768 10.1038/s41568-022-00494-x
institution Sunway University
building Sunway Campus Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Sunway University
content_source Sunway Institutional Repository
url_provider http://eprints.sunway.edu.my/
topic QK Botany
RC Internal medicine
spellingShingle QK Botany
RC Internal medicine
Das, Samrat
Thakur, Shefali
Korenjak, Michael
Sidorenko, Viktoriya S
Chung, Felicia Fei Lei *
Zavadil, Jiri
Aristolochic acid-associated cancers: a public health risk in need of global action
description Aristolochic acids (AAs) are a group of naturally occurring compounds present in many plant species of the Aristolochiaceae family. Exposure to AA is a significant risk factor for severe nephropathy, and urological and hepatobiliary cancers (among others) that are often recurrent and characterized by the prominent mutational fingerprint of AA. However, herbal medicinal products that contain AA continue to be manufactured and marketed worldwide with inadequate regulation, and possible environmental exposure routes receive little attention. As the trade of food and dietary supplements becomes increasingly globalized, we propose that further inaction on curtailing AA exposure will have far-reaching negative effects on the disease trends of AA-associated cancers. Our Review aims to systematically present the historical and current evidence for the mutagenicity and carcinogenicity of AA, and the effect of removing sources of AA exposure on cancer incidence trends. We discuss the persisting challenges of assessing the scale of AA-related carcinogenicity, and the obstacles that must be overcome in curbing AA exposure and preventing associated cancers. Overall, this Review aims to strengthen the case for the implementation of prevention measures against AA's multifaceted, detrimental and potentially fully preventable effects on human cancer development.
format Article
author Das, Samrat
Thakur, Shefali
Korenjak, Michael
Sidorenko, Viktoriya S
Chung, Felicia Fei Lei *
Zavadil, Jiri
author_facet Das, Samrat
Thakur, Shefali
Korenjak, Michael
Sidorenko, Viktoriya S
Chung, Felicia Fei Lei *
Zavadil, Jiri
author_sort Das, Samrat
title Aristolochic acid-associated cancers: a public health risk in need of global action
title_short Aristolochic acid-associated cancers: a public health risk in need of global action
title_full Aristolochic acid-associated cancers: a public health risk in need of global action
title_fullStr Aristolochic acid-associated cancers: a public health risk in need of global action
title_full_unstemmed Aristolochic acid-associated cancers: a public health risk in need of global action
title_sort aristolochic acid-associated cancers: a public health risk in need of global action
publisher Nature Research
publishDate 2022
url http://eprints.sunway.edu.my/3081/
_version_ 1808975638884777984
score 13.222552