A Comprehensive Review on the Therapeutic Potential of Curcuma longa Linn. in Relation to its Major Active Constituent Curcumin
Curcuma longa Linn. (C. longa), popularly known as turmeric, belongs to the Zingiberaceae family and has a long historical background of having healing properties against many diseases. In Unani and Ayurveda medicine, C. longa has been used for liver obstruction and jaundice, and has been applied ex...
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my.sunway.eprints.30352024-08-08T05:10:13Z http://eprints.sunway.edu.my/3035/ A Comprehensive Review on the Therapeutic Potential of Curcuma longa Linn. in Relation to its Major Active Constituent Curcumin Fuloria, Shivkanya Mehta, Jyoti Chandel, Aditi Mahendran, Sekar Nur Najihah, Izzati Mat Rani Begum, M Yasmin Vetriselvan, Subramaniyan Chidambaram, Kumarappan Thangavelu, Lakshmi Rusli, Bin Nordin Wu, Yuan Seng * Kathiresan, V Sathasivam Lum, Pei Teng Meenakshi, Dhanalekshmi Unnikrishnan Vinoth, Kumarasamy Abdul Kalam, Azad Fuloria, Neeraj Kumar QK Botany RA Public aspects of medicine RM Therapeutics. Pharmacology Curcuma longa Linn. (C. longa), popularly known as turmeric, belongs to the Zingiberaceae family and has a long historical background of having healing properties against many diseases. In Unani and Ayurveda medicine, C. longa has been used for liver obstruction and jaundice, and has been applied externally for ulcers and inflammation. Additionally, it is employed in several other ailments such as cough, cold, dental issues, indigestion, skin infections, blood purification, asthma, piles, bronchitis, tumor, wounds, and hepatic disorders, and is used as an antiseptic. Curcumin, a major constituent of C. longa, is well known for its therapeutic potential in numerous disorders. However, there is a lack of literature on the therapeutic potential of C. longa in contrast to curcumin. Hence, the present review aimed to provide in-depth information by highlighting knowledge gaps in traditional and scientific evidence about C. longa in relation to curcumin. The relationship to one another in terms of biological action includes their antioxidant, anti-inflammatory, neuroprotective, anticancer, hepatoprotective, cardioprotective, immunomodulatory, antifertility, antimicrobial, antiallergic, antidermatophytic, and antidepressant properties. Furthermore, in-depth discussion of C. longa on its taxonomic categorization, traditional uses, botanical description, phytochemical ingredients, pharmacology, toxicity, and safety aspects in relation to its major compound curcumin is needed to explore the trends and perspectives for future research. Considering all of the promising evidence to date, there is still a lack of supportive evidence especially from clinical trials on the adjunct use of C. longa and curcumin. This prompts further preclinical and clinical investigations on curcumin. Frontiers Media 2022 Article PeerReviewed Fuloria, Shivkanya and Mehta, Jyoti and Chandel, Aditi and Mahendran, Sekar and Nur Najihah, Izzati Mat Rani and Begum, M Yasmin and Vetriselvan, Subramaniyan and Chidambaram, Kumarappan and Thangavelu, Lakshmi and Rusli, Bin Nordin and Wu, Yuan Seng * and Kathiresan, V Sathasivam and Lum, Pei Teng and Meenakshi, Dhanalekshmi Unnikrishnan and Vinoth, Kumarasamy and Abdul Kalam, Azad and Fuloria, Neeraj Kumar (2022) A Comprehensive Review on the Therapeutic Potential of Curcuma longa Linn. in Relation to its Major Active Constituent Curcumin. Frontiers in Pharmacology, 13. ISSN 1663-9812 https://doi.org/10.3389/fphar.2022.820806 10.3389/fphar.2022.820806 |
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QK Botany RA Public aspects of medicine RM Therapeutics. Pharmacology Fuloria, Shivkanya Mehta, Jyoti Chandel, Aditi Mahendran, Sekar Nur Najihah, Izzati Mat Rani Begum, M Yasmin Vetriselvan, Subramaniyan Chidambaram, Kumarappan Thangavelu, Lakshmi Rusli, Bin Nordin Wu, Yuan Seng * Kathiresan, V Sathasivam Lum, Pei Teng Meenakshi, Dhanalekshmi Unnikrishnan Vinoth, Kumarasamy Abdul Kalam, Azad Fuloria, Neeraj Kumar A Comprehensive Review on the Therapeutic Potential of Curcuma longa Linn. in Relation to its Major Active Constituent Curcumin |
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Curcuma longa Linn. (C. longa), popularly known as turmeric, belongs to the Zingiberaceae family and has a long historical background of having healing properties against many diseases. In Unani and Ayurveda medicine, C. longa has been used for liver obstruction and jaundice, and has been applied externally for ulcers and inflammation. Additionally, it is employed in several other ailments such as cough, cold, dental issues, indigestion, skin infections, blood purification, asthma, piles, bronchitis, tumor, wounds, and hepatic disorders, and is used as an antiseptic. Curcumin, a major constituent of C. longa, is well known for its therapeutic potential in numerous disorders. However, there is a lack of literature on the therapeutic potential of C. longa in contrast to curcumin. Hence, the present review aimed to provide in-depth information by highlighting knowledge gaps in traditional and scientific evidence about C. longa in relation to curcumin. The relationship to one another in terms of biological action includes their antioxidant, anti-inflammatory, neuroprotective, anticancer, hepatoprotective, cardioprotective, immunomodulatory, antifertility, antimicrobial, antiallergic, antidermatophytic, and antidepressant properties. Furthermore, in-depth discussion of C. longa on its taxonomic categorization, traditional uses, botanical description, phytochemical ingredients, pharmacology, toxicity, and safety aspects in relation to its major compound curcumin is needed to explore the trends and perspectives for future research. Considering all of the promising evidence to date, there is still a lack of supportive evidence especially from clinical trials on the adjunct use of C. longa and curcumin. This prompts further preclinical and clinical investigations on curcumin. |
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Fuloria, Shivkanya Mehta, Jyoti Chandel, Aditi Mahendran, Sekar Nur Najihah, Izzati Mat Rani Begum, M Yasmin Vetriselvan, Subramaniyan Chidambaram, Kumarappan Thangavelu, Lakshmi Rusli, Bin Nordin Wu, Yuan Seng * Kathiresan, V Sathasivam Lum, Pei Teng Meenakshi, Dhanalekshmi Unnikrishnan Vinoth, Kumarasamy Abdul Kalam, Azad Fuloria, Neeraj Kumar |
author_facet |
Fuloria, Shivkanya Mehta, Jyoti Chandel, Aditi Mahendran, Sekar Nur Najihah, Izzati Mat Rani Begum, M Yasmin Vetriselvan, Subramaniyan Chidambaram, Kumarappan Thangavelu, Lakshmi Rusli, Bin Nordin Wu, Yuan Seng * Kathiresan, V Sathasivam Lum, Pei Teng Meenakshi, Dhanalekshmi Unnikrishnan Vinoth, Kumarasamy Abdul Kalam, Azad Fuloria, Neeraj Kumar |
author_sort |
Fuloria, Shivkanya |
title |
A Comprehensive Review on the Therapeutic Potential of Curcuma longa Linn. in Relation to its Major Active Constituent Curcumin |
title_short |
A Comprehensive Review on the Therapeutic Potential of Curcuma longa Linn. in Relation to its Major Active Constituent Curcumin |
title_full |
A Comprehensive Review on the Therapeutic Potential of Curcuma longa Linn. in Relation to its Major Active Constituent Curcumin |
title_fullStr |
A Comprehensive Review on the Therapeutic Potential of Curcuma longa Linn. in Relation to its Major Active Constituent Curcumin |
title_full_unstemmed |
A Comprehensive Review on the Therapeutic Potential of Curcuma longa Linn. in Relation to its Major Active Constituent Curcumin |
title_sort |
comprehensive review on the therapeutic potential of curcuma longa linn. in relation to its major active constituent curcumin |
publisher |
Frontiers Media |
publishDate |
2022 |
url |
http://eprints.sunway.edu.my/3035/ https://doi.org/10.3389/fphar.2022.820806 |
_version_ |
1807053658004652032 |
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13.19449 |