Insights on Anticancer Activities, Associated Phytochemicals and Potential Molecular Mechanisms of Quisqualis indica: A Mini Review [Pandangan tentang Aktiviti Antikanser, Fitokimia Berkaitan dan Mekanisme Molekul Berpotensi Quisqualis indica: Suatu Kajian Mini]
Drug resistance is the main issue causing the treatment failure of anticancer drugs. This issue has urged researchers to search for new substances from medicinal plants, which are widely reported as the good sources of anticancer agents. Quisqualis indica is a plant belongs to Combretaceae family, k...
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Universiti Kebangsaan Malaysia
2023
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my.sunway.eprints.28412024-07-22T12:00:16Z http://eprints.sunway.edu.my/2841/ Insights on Anticancer Activities, Associated Phytochemicals and Potential Molecular Mechanisms of Quisqualis indica: A Mini Review [Pandangan tentang Aktiviti Antikanser, Fitokimia Berkaitan dan Mekanisme Molekul Berpotensi Quisqualis indica: Suatu Kajian Mini] Wu, Yuan Seng * Lee, Michelle Felicia * Guad, Rhanye Mac Fathima, Zahraa Ozeer Appalaraju, Velaga Vetriselvan, Subramaniyan Neeraj, Kumar Fuloria Shivkanya, Fuloria Choy, Ker Woon Lee, Sze Meng Subash, C.B. Gopinath Verma, Amita Lau, Tze Pheng * QK Botany RC Internal medicine RS Pharmacy and materia medica Drug resistance is the main issue causing the treatment failure of anticancer drugs. This issue has urged researchers to search for new substances from medicinal plants, which are widely reported as the good sources of anticancer agents. Quisqualis indica is a plant belongs to Combretaceae family, known as Rangoon Creeper, which can be found abundantly in tropical countries and distributed profusely as a wild shrub. It has been widely used traditionally and scientifically claimed to process various therapeutic activities. It has recently been reported to possess various potential anticancer activities against different cancers. Looking at its availability in almost all seasons and grow fast, it is an arising source of herbal medicine in the discovery of anticancer drugs economically. Besides, Q. indica is enriched with several secondary metabolites of interest, which are responsible for the positive findings for its anticancer potentials. In this review, we aim to decipher and discuss the anticancer activities of Q. indica crude extracts and isolated phytochemicals as evidenced in preclinical models, as well as the associated molecular mechanisms. More preclinical investigations on its anticancer potentials should be conducted before translation to clinical testing. Universiti Kebangsaan Malaysia 2023 Article PeerReviewed Wu, Yuan Seng * and Lee, Michelle Felicia * and Guad, Rhanye Mac and Fathima, Zahraa Ozeer and Appalaraju, Velaga and Vetriselvan, Subramaniyan and Neeraj, Kumar Fuloria and Shivkanya, Fuloria and Choy, Ker Woon and Lee, Sze Meng and Subash, C.B. Gopinath and Verma, Amita and Lau, Tze Pheng * (2023) Insights on Anticancer Activities, Associated Phytochemicals and Potential Molecular Mechanisms of Quisqualis indica: A Mini Review [Pandangan tentang Aktiviti Antikanser, Fitokimia Berkaitan dan Mekanisme Molekul Berpotensi Quisqualis indica: Suatu Kajian Mini]. Sains Malaysiana, 52 (6). pp. 1749-1758. ISSN 1749-1758 http://doi.org/10.17576/jsm-2023-5206-11 10.17576/jsm-2023-5206-11 |
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QK Botany RC Internal medicine RS Pharmacy and materia medica Wu, Yuan Seng * Lee, Michelle Felicia * Guad, Rhanye Mac Fathima, Zahraa Ozeer Appalaraju, Velaga Vetriselvan, Subramaniyan Neeraj, Kumar Fuloria Shivkanya, Fuloria Choy, Ker Woon Lee, Sze Meng Subash, C.B. Gopinath Verma, Amita Lau, Tze Pheng * Insights on Anticancer Activities, Associated Phytochemicals and Potential Molecular Mechanisms of Quisqualis indica: A Mini Review [Pandangan tentang Aktiviti Antikanser, Fitokimia Berkaitan dan Mekanisme Molekul Berpotensi Quisqualis indica: Suatu Kajian Mini] |
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Drug resistance is the main issue causing the treatment failure of anticancer drugs. This issue has urged researchers to search for new substances from medicinal plants, which are widely reported as the good sources of anticancer agents. Quisqualis indica is a plant belongs to Combretaceae family, known as Rangoon Creeper, which can be found abundantly in tropical countries and distributed profusely as a wild shrub. It has been widely used traditionally and scientifically claimed to process various therapeutic activities. It has recently been reported to possess various potential anticancer activities against different cancers. Looking at its availability in almost all seasons and grow fast, it is an arising source of herbal medicine in the discovery of anticancer drugs economically. Besides, Q. indica is enriched with several secondary metabolites of interest, which are responsible for the positive findings for its anticancer potentials. In this review, we aim to decipher and discuss the anticancer activities of Q. indica crude extracts and isolated phytochemicals as evidenced in preclinical models, as well as the associated molecular mechanisms. More preclinical investigations on its anticancer potentials should be conducted before translation to clinical testing. |
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Article |
author |
Wu, Yuan Seng * Lee, Michelle Felicia * Guad, Rhanye Mac Fathima, Zahraa Ozeer Appalaraju, Velaga Vetriselvan, Subramaniyan Neeraj, Kumar Fuloria Shivkanya, Fuloria Choy, Ker Woon Lee, Sze Meng Subash, C.B. Gopinath Verma, Amita Lau, Tze Pheng * |
author_facet |
Wu, Yuan Seng * Lee, Michelle Felicia * Guad, Rhanye Mac Fathima, Zahraa Ozeer Appalaraju, Velaga Vetriselvan, Subramaniyan Neeraj, Kumar Fuloria Shivkanya, Fuloria Choy, Ker Woon Lee, Sze Meng Subash, C.B. Gopinath Verma, Amita Lau, Tze Pheng * |
author_sort |
Wu, Yuan Seng * |
title |
Insights on Anticancer Activities, Associated Phytochemicals and Potential Molecular Mechanisms of Quisqualis indica: A Mini Review [Pandangan tentang Aktiviti Antikanser, Fitokimia Berkaitan dan Mekanisme Molekul Berpotensi Quisqualis indica: Suatu Kajian Mini] |
title_short |
Insights on Anticancer Activities, Associated Phytochemicals and Potential Molecular Mechanisms of Quisqualis indica: A Mini Review [Pandangan tentang Aktiviti Antikanser, Fitokimia Berkaitan dan Mekanisme Molekul Berpotensi Quisqualis indica: Suatu Kajian Mini] |
title_full |
Insights on Anticancer Activities, Associated Phytochemicals and Potential Molecular Mechanisms of Quisqualis indica: A Mini Review [Pandangan tentang Aktiviti Antikanser, Fitokimia Berkaitan dan Mekanisme Molekul Berpotensi Quisqualis indica: Suatu Kajian Mini] |
title_fullStr |
Insights on Anticancer Activities, Associated Phytochemicals and Potential Molecular Mechanisms of Quisqualis indica: A Mini Review [Pandangan tentang Aktiviti Antikanser, Fitokimia Berkaitan dan Mekanisme Molekul Berpotensi Quisqualis indica: Suatu Kajian Mini] |
title_full_unstemmed |
Insights on Anticancer Activities, Associated Phytochemicals and Potential Molecular Mechanisms of Quisqualis indica: A Mini Review [Pandangan tentang Aktiviti Antikanser, Fitokimia Berkaitan dan Mekanisme Molekul Berpotensi Quisqualis indica: Suatu Kajian Mini] |
title_sort |
insights on anticancer activities, associated phytochemicals and potential molecular mechanisms of quisqualis indica: a mini review [pandangan tentang aktiviti antikanser, fitokimia berkaitan dan mekanisme molekul berpotensi quisqualis indica: suatu kajian mini] |
publisher |
Universiti Kebangsaan Malaysia |
publishDate |
2023 |
url |
http://eprints.sunway.edu.my/2841/ http://doi.org/10.17576/jsm-2023-5206-11 |
_version_ |
1805893820977512448 |
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13.188404 |