Hepatitis B virus DNA methylation and its potential role in chronic hepatitis B

• Main Authors: Low, Wei Feng *, Ngeow, Yun Fong, Chook, Jack Bee *, Tee, Kok Keng, Ong, Seng Kai *, Peh, Suat Cheng *, Bong, Jan Jin, Rosmawati, Mohamed
• Format: Article
• Published: Cambridge University Press 2023
• Subjects: QH Natural history; R Medicine (General); RC Internal medicine
• Online Access: http://eprints.sunway.edu.my/2817/; https://doi.org/10.1017/erm.2022.38

Hepatitis B virus (HBV) infection led to 66% liver deaths world-wide in year 2015. Thirty-seven per cent of these deaths were the result of chronic hepatitis B (CHB)-associated hepatocellular carcinoma (HCC). Although early diagnosis of HCC improves survival, early detection is rare. Methylation of...