The Design, Synthesis, and Evaluation of Diaminopimelic Acid Derivatives as Potential dapF Inhibitors Preventing Lysine Biosynthesis for Antibacterial Activity

• Main Authors: Shaikh, Mohd Sayeed, Kale, Mayura A., Muralidharan, V., Venkatachalam, T., Ali, Syed Sarfaraz, Islam, Fahadul, Khan, Sharuk L., Siddiqui, Falak A., Urmee, Humaira, Tapadiya, Ganesh G., Dhawale, Sachin A., Long, Chiau Ming *, Ibrahim, Ibrahim Abdel Aziz, Alzahrani, Abdullah R., Sarker, Md. Moklesur Rahman, Mohd Fahami, Nur Azlina
• Format: Article
• Language: English
• Published: MDPI 2023
• Subjects: QP Physiology; RM Therapeutics. Pharmacology
• Online Access: http://eprints.sunway.edu.my/2784/1/Long%20Chiau%20Ming_Design%20synthesis%20and%20evaluation%20of%20diaminopimelic%20acid.pdf; http://eprints.sunway.edu.my/2784/; https://doi.org/10.3390/antibiotics12010047

We created thiazole and oxazole analogues of diaminopimelic acid (DAP) by replacing its carboxyl groups and substituting sulphur for the central carbon atom. Toxicity, ADME, molecular docking, and in vitro antimicrobial studies of the synthesized compounds were carried out. These compounds displayed...