Celastrol: A Potential Natural Lead Molecule for New Drug Design, Development and Therapy for Memory Impairment

• Main Authors: Muhamad Azrul, Amir Yusri, Mahendran, Sekar, Wong, Ling Shing, Gan, Siew Hua, Ravi, Subban, Vetriselvan, Subramaniyan, Nur Najihah, Izzati Mat Rani, Chidambaram, Kumarappan, Begum, M Yasmin, Ramar, Mohankumar, Sher Zaman, Safi, Siddharthan, Selvaraj, Wu, Yuan Seng *, Revathy, Palanisamy, Fuloria, Shivkanya, Fuloria, Neeraj Kumar, Lum, Pei Teng, Sinouvassane, Djearamane
• Format: Article
• Language: English
• Published: Dove Press 2023
• Subjects: QD Chemistry; QH Natural history; RC Internal medicine; RS Pharmacy and materia medica
• Online Access: http://eprints.sunway.edu.my/2776/1/Wu%20Yuan%20Seng_Celastrol%20a%20potential%20natural%20lead%20molecule%20for%20new%20drug%20design.pdf; http://eprints.sunway.edu.my/2776/; https://doi.org/10.2147/DDDT.S389977

Celastrol is a naturally occurring chemical isolated from Tripterygium wilfordii Hook. f., root extracts widely known for their neuroprotective properties. In this review, we focus on the efficacy of celastrol in mitigating memory impairment (MI) in both in vivo and in vitro models. Scopus, PubMed a...