A tryptophan metabolite made by a gut microbiome eukaryote induces pro-inflammatory T cells

• Main Authors: Wojciech, Lukasz, Png, Chin Wen, Koh, Eileen Y, Kioh, Dorinda Yan Qin, Deng, Lei, Wang, Ziteng, Wu, Liang Zhe, Hamidinia, Maryam, Tung, Desmond Wh, Zhang, Wei, Pettersson, Sven *, Chan, Eric Chun Yong, Zhang, Yongliang, Tan, Kevin Sw, Gascoigne, Nicholas Rj
• Format: Article
• Published: EMBO Press 2023
• Subjects: QP Physiology; QR Microbiology; RC Internal medicine
• Online Access: http://eprints.sunway.edu.my/2754/; https://doi.org/10.15252/embj.2022112963

The large intestine harbors microorganisms playing unique roles in host physiology. The beneficial or detrimental outcome of host-microbiome coexistence depends largely on the balance between regulators and responder intestinal CD4+ T cells. We found that ulcerative colitis-like changes in the large...