Anti-amoebic effects of synthetic acridine-9(10H)-one against brain-eating amoebae

• Main Authors: Usman, Ahmed *, Manzoor, Mehwish, Qureshi, Sehrish, Mazhar, Muzna, Fatima, Arj, Aurangzeb, Sana, Hamid, Mehwish, Khan, Khalid Mohammed, Khan, Naveed Ahmed, Rashid, Yasmeen, Ayaz, Anwar *
• Format: Article
• Published: Elsevier 2023
• Subjects: QH Natural history; QL Zoology; QR Microbiology
• Online Access: http://eprints.sunway.edu.my/2736/; https://doi.org/10.1016/j.actatropica.2023.106824

Pathogenic A. castellanii and N. fowleri are opportunistic free-living amoebae. Acanthamoeba spp. are the causative agents of granulomatous amebic encephalitis (GAE) and amebic keratitis (AK), whereas Naegleria fowleri causes a very rare but severe brain infection called primary amebic meningoenceph...