The Emerging Role of MMP12 in the Oral Environment
Matrix metalloproteinase-12 (MMP12), or macrophage metalloelastase, plays important roles in extracellular matrix (ECM) component degradation. Recent reports show MMP12 has been implicated in the pathogenesis of periodontal diseases. To date, this review represents the latest comprehensive overview...
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my.sunway.eprints.27352024-07-05T03:14:36Z http://eprints.sunway.edu.my/2735/ The Emerging Role of MMP12 in the Oral Environment Lin, Bingpeng Ser, Hooi Leng * Wang, Lijing Li, Jiang Chan, Kok Gan Lee, Learn-Han Tan Loh, Teng Hern QR Microbiology RK Dentistry Matrix metalloproteinase-12 (MMP12), or macrophage metalloelastase, plays important roles in extracellular matrix (ECM) component degradation. Recent reports show MMP12 has been implicated in the pathogenesis of periodontal diseases. To date, this review represents the latest comprehensive overview of MMP12 in various oral diseases, such as periodontitis, temporomandibular joint dysfunction (TMD), orthodontic tooth movement (OTM), and oral squamous cell carcinoma (OSCC). Furthermore, the current knowledge regarding the distribution of MMP12 in different tissues is also illustrated in this review. Studies have implicated the association of MMP12 expression with the pathogenesis of several representative oral diseases, including periodontitis, TMD, OSCC, OTM, and bone remodelling. Although there may be a potential role of MMP12 in oral diseases, the exact pathophysiological role of MMP12 remains to be elucidated. Understanding the cellular and molecular biology of MMP12 is essential, as MMP12 could be a potential target for developing therapeutic strategies targeting inflammatory and immunologically related oral diseases. MDPI 2023 Article PeerReviewed text en cc_by_4 http://eprints.sunway.edu.my/2735/1/Ser%20Hooi%20Leng_Emerging%20role%20of%20MMP12.pdf Lin, Bingpeng and Ser, Hooi Leng * and Wang, Lijing and Li, Jiang and Chan, Kok Gan and Lee, Learn-Han and Tan Loh, Teng Hern (2023) The Emerging Role of MMP12 in the Oral Environment. International Journal of Molecular Sciences, 24 (5). ISSN 1422-0067 https://doi.org/10.3390/ijms24054648 10.3390/ijms24054648 |
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Matrix metalloproteinase-12 (MMP12), or macrophage metalloelastase, plays important roles in extracellular matrix (ECM) component degradation. Recent reports show MMP12 has been implicated in the pathogenesis of periodontal diseases. To date, this review represents the latest comprehensive overview of MMP12 in various oral diseases, such as periodontitis, temporomandibular joint dysfunction (TMD), orthodontic tooth movement (OTM), and oral squamous cell carcinoma (OSCC). Furthermore, the current knowledge regarding the distribution of MMP12 in different tissues is also illustrated in this review. Studies have implicated the association of MMP12 expression with the pathogenesis of several representative oral diseases, including periodontitis, TMD, OSCC, OTM, and bone remodelling. Although there may be a potential role of MMP12 in oral diseases, the exact pathophysiological role of MMP12 remains to be elucidated. Understanding the cellular and molecular biology of MMP12 is essential, as MMP12 could be a potential target for developing therapeutic strategies targeting inflammatory and immunologically related oral diseases. |
format |
Article |
author |
Lin, Bingpeng Ser, Hooi Leng * Wang, Lijing Li, Jiang Chan, Kok Gan Lee, Learn-Han Tan Loh, Teng Hern |
author_facet |
Lin, Bingpeng Ser, Hooi Leng * Wang, Lijing Li, Jiang Chan, Kok Gan Lee, Learn-Han Tan Loh, Teng Hern |
author_sort |
Lin, Bingpeng |
title |
The Emerging Role of MMP12 in the Oral Environment |
title_short |
The Emerging Role of MMP12 in the Oral Environment |
title_full |
The Emerging Role of MMP12 in the Oral Environment |
title_fullStr |
The Emerging Role of MMP12 in the Oral Environment |
title_full_unstemmed |
The Emerging Role of MMP12 in the Oral Environment |
title_sort |
emerging role of mmp12 in the oral environment |
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MDPI |
publishDate |
2023 |
url |
http://eprints.sunway.edu.my/2735/1/Ser%20Hooi%20Leng_Emerging%20role%20of%20MMP12.pdf http://eprints.sunway.edu.my/2735/ https://doi.org/10.3390/ijms24054648 |
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1804069664838385664 |
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13.18916 |