Chitosan coated magnetic cellulose nanowhisker as a drug delivery system for potential colorectal cancer treatment
Polysaccharide-based magnetic nanocomposites can eminently illuminate several attractive features as anticancer drug carriers. In this study, rice straw-based cellulose nanowhisker (CNW) was used as solid support for Fe3O4 nanofillers to synthesize magnetic CNW. Then, cross-linked chitosan-coated ma...
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my.sunway.eprints.27312024-07-04T01:25:33Z http://eprints.sunway.edu.my/2731/ Chitosan coated magnetic cellulose nanowhisker as a drug delivery system for potential colorectal cancer treatment Mostafa, Yusefi Shameli, Kamyar Soon, Michiele Lee Kiun * Teow, Sin Yeang Moeini, Hassan Roshafima, Rasit Ali Pooneh, Kia Jie, Chia Jing Nurul Hidayah, Abdullah QR Microbiology RC Internal medicine TP Chemical technology Polysaccharide-based magnetic nanocomposites can eminently illuminate several attractive features as anticancer drug carriers. In this study, rice straw-based cellulose nanowhisker (CNW) was used as solid support for Fe3O4 nanofillers to synthesize magnetic CNW. Then, cross-linked chitosan-coated magnetic CNW for 5-fluorouracil carrier abbreviated as CH/MCNW/5FU. Fourier-transform infrared, X-Ray diffraction, and X-ray photoelectron spectroscopy analysis indicated successful fabrication and multifunctional properties of the CH/MCNW/5FU nanocomposites. In addition, CH/MCNW/5FU nanocomposites showed hydrodynamic diameter and zeta potential value of 181.31 ± 3.46 nm and +23 ± 1.8 mV, respectively. Based on images of transmission electron microscopy, magnetic CNW as reinforcement was coated with chitosan to obtain almost spherical CH/MCNW/5FU nanocomposites with an average diameter of 37.16 ± 3.08. The nanocomposites indicated desired saturation magnetization and thermal stability, high drug encapsulation efficiency, and pH-dependent swelling and drug release performance. CH/MCNW/5FU nanocomposites showed potent killing effects against colorectal cancer cells in both 2D monolayer and 3D spheroid models. These findings suggest CH/MCNW as a potential carrier for anticancer drugs with high tumour-penetrating capacity. Elsevier 2023 Article PeerReviewed Mostafa, Yusefi and Shameli, Kamyar and Soon, Michiele Lee Kiun * and Teow, Sin Yeang and Moeini, Hassan and Roshafima, Rasit Ali and Pooneh, Kia and Jie, Chia Jing and Nurul Hidayah, Abdullah (2023) Chitosan coated magnetic cellulose nanowhisker as a drug delivery system for potential colorectal cancer treatment. International Journal of Biological Macromolecules, 233. ISSN 1879-0003 https://doi.org/10.1016/j.ijbiomac.2023.123388 10.1016/j.ijbiomac.2023.123388 |
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QR Microbiology RC Internal medicine TP Chemical technology Mostafa, Yusefi Shameli, Kamyar Soon, Michiele Lee Kiun * Teow, Sin Yeang Moeini, Hassan Roshafima, Rasit Ali Pooneh, Kia Jie, Chia Jing Nurul Hidayah, Abdullah Chitosan coated magnetic cellulose nanowhisker as a drug delivery system for potential colorectal cancer treatment |
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Polysaccharide-based magnetic nanocomposites can eminently illuminate several attractive features as anticancer drug carriers. In this study, rice straw-based cellulose nanowhisker (CNW) was used as solid support for Fe3O4 nanofillers to synthesize magnetic CNW. Then, cross-linked chitosan-coated magnetic CNW for 5-fluorouracil carrier abbreviated as CH/MCNW/5FU. Fourier-transform infrared, X-Ray diffraction, and X-ray photoelectron spectroscopy analysis indicated successful fabrication and multifunctional properties of the CH/MCNW/5FU nanocomposites. In addition, CH/MCNW/5FU nanocomposites showed hydrodynamic diameter and zeta potential value of 181.31 ± 3.46 nm and +23 ± 1.8 mV, respectively. Based on images of transmission electron microscopy, magnetic CNW as reinforcement was coated with chitosan to obtain almost spherical CH/MCNW/5FU nanocomposites with an average diameter of 37.16 ± 3.08. The nanocomposites indicated desired saturation magnetization and thermal stability, high drug encapsulation efficiency, and pH-dependent swelling and drug release performance. CH/MCNW/5FU nanocomposites showed potent killing effects against colorectal cancer cells in both 2D monolayer and 3D spheroid models. These findings suggest CH/MCNW as a potential carrier for anticancer drugs with high tumour-penetrating capacity. |
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Article |
author |
Mostafa, Yusefi Shameli, Kamyar Soon, Michiele Lee Kiun * Teow, Sin Yeang Moeini, Hassan Roshafima, Rasit Ali Pooneh, Kia Jie, Chia Jing Nurul Hidayah, Abdullah |
author_facet |
Mostafa, Yusefi Shameli, Kamyar Soon, Michiele Lee Kiun * Teow, Sin Yeang Moeini, Hassan Roshafima, Rasit Ali Pooneh, Kia Jie, Chia Jing Nurul Hidayah, Abdullah |
author_sort |
Mostafa, Yusefi |
title |
Chitosan coated magnetic cellulose nanowhisker as a drug delivery system for potential colorectal cancer treatment |
title_short |
Chitosan coated magnetic cellulose nanowhisker as a drug delivery system for potential colorectal cancer treatment |
title_full |
Chitosan coated magnetic cellulose nanowhisker as a drug delivery system for potential colorectal cancer treatment |
title_fullStr |
Chitosan coated magnetic cellulose nanowhisker as a drug delivery system for potential colorectal cancer treatment |
title_full_unstemmed |
Chitosan coated magnetic cellulose nanowhisker as a drug delivery system for potential colorectal cancer treatment |
title_sort |
chitosan coated magnetic cellulose nanowhisker as a drug delivery system for potential colorectal cancer treatment |
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Elsevier |
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2023 |
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http://eprints.sunway.edu.my/2731/ https://doi.org/10.1016/j.ijbiomac.2023.123388 |
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1804069664272154624 |
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