Novel Tetrazoles against Acanthamoeba Castellanii belonging to the T4 genotype

• Main Authors: Yassmin, Isse Wehelie *, Khan, Naveed Ahmed, Fatima, Itrat, Anwar, Areeba, Kanwal, Kanwal, Khan, Khalid Mohammed, Siddiqui, Ruqaiyyah, Tong, Tommy Yuh Koon *, Ayaz, Anwar *
• Format: Article
• Published: S. Karger AG 2021
• Subjects: QR Microbiology
• Online Access: http://eprints.sunway.edu.my/2625/; https://doi.org/10.1159/000520585

Background: Acanthamoeba castellanii is a pathogenic freeliving amoeba responsible for blinding keratitis and fatal granulomatous amoebic encephalitis. However, treatments are not standardized but can involve the use of amidines, biguanides, and azoles. Objectives: The aim of this study was to synth...