Beta-actin variant is necessary for Enterovirus 71 replication
Enterovirus 71 (EV71) is one of the main etiological agents of the Hand, Foot and Mouth Disease (HFMD) and has been known to cause fatal neurological complications such as herpangina, aseptic meningitis, poliomyelitis-like paralysis and encephalitis. EV71 is endemic in the Asia-Pacific region and ca...
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my.sunway.eprints.1962019-04-22T05:08:28Z http://eprints.sunway.edu.my/196/ Beta-actin variant is necessary for Enterovirus 71 replication Lui, Edmund Yan Long Lin, Zhiyang Lee, Jia Jun Chow, Vincent Tak Kwong Poh, Chit Laa * Tan, Eng Lee QH301 Biology Enterovirus 71 (EV71) is one of the main etiological agents of the Hand, Foot and Mouth Disease (HFMD) and has been known to cause fatal neurological complications such as herpangina, aseptic meningitis, poliomyelitis-like paralysis and encephalitis. EV71 is endemic in the Asia-Pacific region and causes occasional epidemics. In order to better understand EV71 infection, we compared the proteome between EV71-susceptible and EV71-resistant human Rhabdomyosarcom a(RD)cell line. We found significant differences in the b-actin variants between the EV71-susceptible RD cells and EV71-resistant RD cells, suggesting that b-actin, in association with other proteins such as annexin 2 is required in vesicular transport of EV71. This finding further support our previous study that actin potentially plays a role in pathogenesis and the establishment of the disease in HFMD. Elsevier 2013-04-19 Article PeerReviewed Lui, Edmund Yan Long and Lin, Zhiyang and Lee, Jia Jun and Chow, Vincent Tak Kwong and Poh, Chit Laa * and Tan, Eng Lee (2013) Beta-actin variant is necessary for Enterovirus 71 replication. Biochemical and Biophysical Research Communications, 433 (4). pp. 607-610. ISSN 0006-291X http://dx.doi.org/10.1016/j.bbrc.2013.03.044 |
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QH301 Biology Lui, Edmund Yan Long Lin, Zhiyang Lee, Jia Jun Chow, Vincent Tak Kwong Poh, Chit Laa * Tan, Eng Lee Beta-actin variant is necessary for Enterovirus 71 replication |
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Enterovirus 71 (EV71) is one of the main etiological agents of the Hand, Foot and Mouth Disease (HFMD) and has been known to cause fatal neurological complications such as herpangina, aseptic meningitis, poliomyelitis-like paralysis and encephalitis. EV71 is endemic in the Asia-Pacific region and causes occasional epidemics. In order to better understand EV71 infection, we compared the proteome between
EV71-susceptible and EV71-resistant human Rhabdomyosarcom a(RD)cell line. We found significant differences in the b-actin variants between the EV71-susceptible RD cells and EV71-resistant RD cells, suggesting that b-actin, in association with other proteins such as annexin 2 is required in vesicular transport of EV71. This finding further support our previous study that actin potentially plays a role in pathogenesis and the establishment of the disease in HFMD. |
format |
Article |
author |
Lui, Edmund Yan Long Lin, Zhiyang Lee, Jia Jun Chow, Vincent Tak Kwong Poh, Chit Laa * Tan, Eng Lee |
author_facet |
Lui, Edmund Yan Long Lin, Zhiyang Lee, Jia Jun Chow, Vincent Tak Kwong Poh, Chit Laa * Tan, Eng Lee |
author_sort |
Lui, Edmund Yan Long |
title |
Beta-actin variant is necessary for Enterovirus 71 replication |
title_short |
Beta-actin variant is necessary for Enterovirus 71 replication |
title_full |
Beta-actin variant is necessary for Enterovirus 71 replication |
title_fullStr |
Beta-actin variant is necessary for Enterovirus 71 replication |
title_full_unstemmed |
Beta-actin variant is necessary for Enterovirus 71 replication |
title_sort |
beta-actin variant is necessary for enterovirus 71 replication |
publisher |
Elsevier |
publishDate |
2013 |
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http://eprints.sunway.edu.my/196/ http://dx.doi.org/10.1016/j.bbrc.2013.03.044 |
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