Radiation, a two-edged sword: From untoward effects to fractionated radiotherapy
Radiations in medicine cover a wide range of applications, predominantly in diagnostic imaging and radiotherapy, encompassing photons (x- andγ-rays) and particle radiation, as well as with the use of liquid sources in nuclear medicine focusing on physiological functional imaging, tumour detection or...
Saved in:
Main Authors: | , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Elsevier
2021
|
Subjects: | |
Online Access: | http://eprints.sunway.edu.my/1542/1/Chew%20Ming%20Tsuey%20Radiation-a%20two-edged%20sword-from%20untowards%20effects%20to%20fractionated%20radiotherapy.pdf http://eprints.sunway.edu.my/1542/ http://doi.org/10.1016/j.radphyschem.2020.108994 |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
id |
my.sunway.eprints.1542 |
---|---|
record_format |
eprints |
spelling |
my.sunway.eprints.15422020-12-14T03:46:45Z http://eprints.sunway.edu.my/1542/ Radiation, a two-edged sword: From untoward effects to fractionated radiotherapy Chew, Ming Tsuey * Jones, B. Hill, M. Bradley, D.A. R895-920 Medical Physics/Medical Radiology Radiations in medicine cover a wide range of applications, predominantly in diagnostic imaging and radiotherapy, encompassing photons (x- andγ-rays) and particle radiation, as well as with the use of liquid sources in nuclear medicine focusing on physiological functional imaging, tumour detection or targeted radiotherapy. The biological interactions of ionizing radiation leads naturally to questions of benefits and risk following dose exposures. The inherent properties of ionizing radiation in sterilising dividing cells can offer immense benefits withrespectto tumourcontrol,butradiationcanalsodeliverpotentialharminthe formofnormaltissue toxicity or carcinogenesis. The advances in radiation technology, offering accurate and reliable dose delivery, in concert with greater understanding of the underpinning radiobiological effects are creating an ever-growing ability to extract maximum benefit and minimise risk. The radiobiological effects fall broadly under the headings of mutagenesis, chromosomal aberrations, radiation induced genomic instability and cell death. The enormity of evidence derived from these underlie the mechanism of the six Rs of controlled radiotherapy: repair, repopulation, reoxygenation, redistribution, radiosensitivity and most recently, remote bystander cellular effects (including low dose hyper-radiosensitivity, adaptive response, hormesis, abscopal effect and immune response). Herein, we seek to discuss how such understanding leads to optimised radiotherapy. Elsevier 2021-05-26 Article PeerReviewed text en cc_by_nc_4 http://eprints.sunway.edu.my/1542/1/Chew%20Ming%20Tsuey%20Radiation-a%20two-edged%20sword-from%20untowards%20effects%20to%20fractionated%20radiotherapy.pdf Chew, Ming Tsuey * and Jones, B. and Hill, M. and Bradley, D.A. (2021) Radiation, a two-edged sword: From untoward effects to fractionated radiotherapy. Radiation Physics and Chemistry, 178. p. 108994. ISSN 0969-806X http://doi.org/10.1016/j.radphyschem.2020.108994 doi:10.1016/j.radphyschem.2020.108994 |
institution |
Sunway University |
building |
Sunway Campus Library |
collection |
Institutional Repository |
continent |
Asia |
country |
Malaysia |
content_provider |
Sunway University |
content_source |
Sunway Institutional Repository |
url_provider |
http://eprints.sunway.edu.my/ |
language |
English |
topic |
R895-920 Medical Physics/Medical Radiology |
spellingShingle |
R895-920 Medical Physics/Medical Radiology Chew, Ming Tsuey * Jones, B. Hill, M. Bradley, D.A. Radiation, a two-edged sword: From untoward effects to fractionated radiotherapy |
description |
Radiations in medicine cover a wide range of applications, predominantly in diagnostic imaging and radiotherapy, encompassing photons (x- andγ-rays) and particle radiation, as well as with the use of liquid sources in nuclear medicine focusing on physiological functional imaging, tumour detection or targeted radiotherapy. The biological interactions of ionizing radiation leads naturally to questions of benefits and risk following dose exposures. The inherent properties of ionizing radiation in sterilising dividing cells can offer immense benefits withrespectto tumourcontrol,butradiationcanalsodeliverpotentialharminthe formofnormaltissue toxicity or carcinogenesis. The advances in radiation technology, offering accurate and reliable dose delivery, in concert with greater understanding of the underpinning radiobiological effects are creating an ever-growing ability to extract maximum benefit and minimise risk. The radiobiological effects fall broadly under the headings of mutagenesis, chromosomal aberrations, radiation induced genomic instability and cell death. The enormity of evidence derived from these underlie the mechanism of the six Rs of controlled radiotherapy: repair, repopulation, reoxygenation, redistribution, radiosensitivity and most recently, remote bystander cellular effects (including low dose hyper-radiosensitivity, adaptive response, hormesis, abscopal effect and immune response). Herein, we seek to discuss how such understanding leads to optimised radiotherapy. |
format |
Article |
author |
Chew, Ming Tsuey * Jones, B. Hill, M. Bradley, D.A. |
author_facet |
Chew, Ming Tsuey * Jones, B. Hill, M. Bradley, D.A. |
author_sort |
Chew, Ming Tsuey * |
title |
Radiation, a two-edged sword: From untoward effects to fractionated radiotherapy |
title_short |
Radiation, a two-edged sword: From untoward effects to fractionated radiotherapy |
title_full |
Radiation, a two-edged sword: From untoward effects to fractionated radiotherapy |
title_fullStr |
Radiation, a two-edged sword: From untoward effects to fractionated radiotherapy |
title_full_unstemmed |
Radiation, a two-edged sword: From untoward effects to fractionated radiotherapy |
title_sort |
radiation, a two-edged sword: from untoward effects to fractionated radiotherapy |
publisher |
Elsevier |
publishDate |
2021 |
url |
http://eprints.sunway.edu.my/1542/1/Chew%20Ming%20Tsuey%20Radiation-a%20two-edged%20sword-from%20untowards%20effects%20to%20fractionated%20radiotherapy.pdf http://eprints.sunway.edu.my/1542/ http://doi.org/10.1016/j.radphyschem.2020.108994 |
_version_ |
1687396525348487168 |
score |
13.18916 |