Basic pathogenic mechanisms of atherosclerosis
Atherosclerosis is a chronic inflammatory disease of the inner wall of large and medium-sized arteries. It is a disease of multiple causes which regarded as the primary underlying cause of heart diseases and cerebrovascular accidents. Pathologically, atherosclerosis is a chronic arterial inflammati...
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my.iium.irep.981382022-06-02T00:34:12Z http://irep.iium.edu.my/98138/ Basic pathogenic mechanisms of atherosclerosis Alfarisi, Hamad Hamad Mohamed, Zenab B. Ibrahim, Muhammad RC667 Specialties of Internal Medicine-Diseases of Circulatory (Cardiovascular) System Atherosclerosis is a chronic inflammatory disease of the inner wall of large and medium-sized arteries. It is a disease of multiple causes which regarded as the primary underlying cause of heart diseases and cerebrovascular accidents. Pathologically, atherosclerosis is a chronic arterial inflammation secondary to prolonged exposure to oxidative stressors and involves multiple cell types and cellular mediators. Oxidized lipids derived from low-density lipoprotein contribute to multiple stages of atherosclerotic plaque development and progression through production of inflammatory cytokines. Diet and dietary habits are the major driving forces for development and modification of atherosclerotic diseases. Genetics and epigenetics have a significant influence on development and progression of atherosclerosis. Future therapeutic options may target the pathogenic mediators of atherosclerosis at multiple molecular levels. Taylor & Francis 2020-06-02 Article PeerReviewed application/pdf en http://irep.iium.edu.my/98138/1/98138_Basic%20pathogenic%20mechanisms.pdf Alfarisi, Hamad and Hamad Mohamed, Zenab B. and Ibrahim, Muhammad (2020) Basic pathogenic mechanisms of atherosclerosis. Egyptian Journal of Basic and Applied Sciences, 7 (1). pp. 116-125. E-ISSN 2314-808X https://www.tandfonline.com/doi/epub/10.1080/2314808X.2020.1769913?needAccess=true 10.1080/2314808X.2020.1769913 |
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RC667 Specialties of Internal Medicine-Diseases of Circulatory (Cardiovascular) System Alfarisi, Hamad Hamad Mohamed, Zenab B. Ibrahim, Muhammad Basic pathogenic mechanisms of atherosclerosis |
description |
Atherosclerosis is a chronic inflammatory disease of the inner wall of large and medium-sized arteries. It is a disease of multiple causes which regarded
as the primary underlying cause of heart diseases and cerebrovascular accidents. Pathologically, atherosclerosis is a chronic arterial inflammation secondary to prolonged exposure to oxidative stressors and involves multiple
cell types and cellular mediators. Oxidized lipids derived from low-density
lipoprotein contribute to multiple stages of atherosclerotic plaque development and progression through production of inflammatory cytokines. Diet
and dietary habits are the major driving forces for development and modification of atherosclerotic diseases. Genetics and epigenetics have
a significant influence on development and progression of atherosclerosis.
Future therapeutic options may target the pathogenic mediators of atherosclerosis at multiple molecular levels. |
format |
Article |
author |
Alfarisi, Hamad Hamad Mohamed, Zenab B. Ibrahim, Muhammad |
author_facet |
Alfarisi, Hamad Hamad Mohamed, Zenab B. Ibrahim, Muhammad |
author_sort |
Alfarisi, Hamad |
title |
Basic pathogenic mechanisms of atherosclerosis |
title_short |
Basic pathogenic mechanisms of atherosclerosis |
title_full |
Basic pathogenic mechanisms of atherosclerosis |
title_fullStr |
Basic pathogenic mechanisms of atherosclerosis |
title_full_unstemmed |
Basic pathogenic mechanisms of atherosclerosis |
title_sort |
basic pathogenic mechanisms of atherosclerosis |
publisher |
Taylor & Francis |
publishDate |
2020 |
url |
http://irep.iium.edu.my/98138/1/98138_Basic%20pathogenic%20mechanisms.pdf http://irep.iium.edu.my/98138/ https://www.tandfonline.com/doi/epub/10.1080/2314808X.2020.1769913?needAccess=true |
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1735386636983730176 |
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13.19449 |