Synthesis of nanoherbal from ethanol extract of Indonesian fern selaginella plana and antibacterial activity assay
Selaginella plana is one of the ferns that grows widely in Indonesia and has been used by the people as food, ornamental plants and traditional medicine. The preparation of S. plana extract in the form of nanoparticles can overcome the weakness of the extract, namely the low water solubility, bio...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
2022
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| Subjects: | |
| Online Access: | http://irep.iium.edu.my/96681/7/96681_Synthesis%20of%20Nanoherbal%20from%20Ethanol%20Extract.pdf http://irep.iium.edu.my/96681/ https://www.tjnpr.org/ |
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| Summary: | Selaginella plana is one of the ferns that grows widely in Indonesia and has been used by the
people as food, ornamental plants and traditional medicine. The preparation of S. plana extract
in the form of nanoparticles can overcome the weakness of the extract, namely the low water
solubility, bioavailability, stability, and absorption so as to increase its efficacy as a herbal
medicine. Research related to the synthesis of nanoherbal from Selaginella plana as an
antibacterial had never been reported. This study aims to synthesize nanoherbal from the ethanol
extract of S. plana and test for its antibacterial activity. Extraction was carried out by maceration
method, synthesis of nanoherbal by ionic gelation method, and antibacterial assay by disc
diffusion method. The synthesized nanoherbal were characterized by FT-IR spectrophotometer,
zetasizer nano, and scanning electron microscopy (SEM). The results showed that nanoherb of
formula-1 (F-1) had a particle size in nanoparticle range (701.5467.72 nm) and had a zeta
potential of +499.378.00 mV. The shift on the stretching vibration of the O-H group (3370.12
cm
-1
), the bending vibration of the N-H (1563.55 cm-1
), and the appearance of the vibration of
the phosphate group (1083.86 cm-1
) supported the formation of nanoherbal in F-1. The F-1
nanoherbal has very strong antibacterial activity against E. coli, S. dysentriae, and S. aureus as
well as strong antibacterial activity against B. subtilis. It showed stronger antibacterial activity
than the ethanol extract of Selaginella plana. Thus the F-1 nanoherbal has the potential to be
developed as an antibacterial agent |
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