A preliminary study on the effects of Stingless Bee Honey (SBH) on fasting blood glucose in Streptozotocin (STZ)-Induced diabetic rat models
Diabetes is a metabolic disorder characterized by hyperglycemia due to defects in insulin secretion, insulin action, or both. SBH has good antihyperglycemic potential and has traditionally been used as an alternative treatment for diabetes mellitus (DM). Since the role of SBH in glucose control is s...
Saved in:
Main Authors: | , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Malaysian Society of Applied Biology
2021
|
Subjects: | |
Online Access: | http://irep.iium.edu.my/95752/1/95752-A%20preliminary%20study%20on%20the%20effects%20of%20Stingless%20Bee%20Honey.pdf http://irep.iium.edu.my/95752/ https://jms.mabjournal.com/index.php/mab |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
id |
my.iium.irep.95752 |
---|---|
record_format |
dspace |
spelling |
my.iium.irep.957522021-12-30T03:58:01Z http://irep.iium.edu.my/95752/ A preliminary study on the effects of Stingless Bee Honey (SBH) on fasting blood glucose in Streptozotocin (STZ)-Induced diabetic rat models Ismail, Anis Farihan Mohd Nasir, Suriati Tuan Ismail, Tuan Salwani Wan Ahmad, Wan Amir Nizam Wan Abdul Rahman, Wan Faiziah Kuttulebbai Naina Mohamed Salam, Sirajudeen Tengku Din, Tengku Ahmad Damitri Al-Astani R Medicine (General) Diabetes is a metabolic disorder characterized by hyperglycemia due to defects in insulin secretion, insulin action, or both. SBH has good antihyperglycemic potential and has traditionally been used as an alternative treatment for diabetes mellitus (DM). Since the role of SBH in glucose control is still unclear in animal and human studies, the present study was designed to evaluate the antihyperglycemic effects of SBH in streptozotocin-induced diabetic rat models. Fifteen Sprague-Dawley rats (200-250 g) were equally divided into five groups, the first group being a normal (non-diabetic) rat and the other four groups being diabetic. The normal and untreated diabetic groups received normal saline while the other diabetic groups were treated with SBH (2 g/kg body weight), metformin (MET /250 mg/kg body weight) and SBH + MET respectively.The treatment was given within 12 days. Fasting blood glucose (FBG) was measured at baseline and every two weeks thereafter. On days 7 and 12, SBH significantly lowered FBG, comparable to the normal group (p<0.05). In the group treated with MET and the combination of SBH-MET, FBG improved only on the 12th day of treatment (p<0.05). The results show that a single SBH treatment is effective in lowering blood glucose levels. Thus, SBH could be of great value in the treatment of diabetes in humans Malaysian Society of Applied Biology 2021-11-30 Article PeerReviewed application/pdf en http://irep.iium.edu.my/95752/1/95752-A%20preliminary%20study%20on%20the%20effects%20of%20Stingless%20Bee%20Honey.pdf Ismail, Anis Farihan and Mohd Nasir, Suriati and Tuan Ismail, Tuan Salwani and Wan Ahmad, Wan Amir Nizam and Wan Abdul Rahman, Wan Faiziah and Kuttulebbai Naina Mohamed Salam, Sirajudeen and Tengku Din, Tengku Ahmad Damitri Al-Astani (2021) A preliminary study on the effects of Stingless Bee Honey (SBH) on fasting blood glucose in Streptozotocin (STZ)-Induced diabetic rat models. Malaysian Applied Biology, 50 (2). pp. 151-156. ISSN 2462-151X https://jms.mabjournal.com/index.php/mab |
institution |
Universiti Islam Antarabangsa Malaysia |
building |
IIUM Library |
collection |
Institutional Repository |
continent |
Asia |
country |
Malaysia |
content_provider |
International Islamic University Malaysia |
content_source |
IIUM Repository (IREP) |
url_provider |
http://irep.iium.edu.my/ |
language |
English |
topic |
R Medicine (General) |
spellingShingle |
R Medicine (General) Ismail, Anis Farihan Mohd Nasir, Suriati Tuan Ismail, Tuan Salwani Wan Ahmad, Wan Amir Nizam Wan Abdul Rahman, Wan Faiziah Kuttulebbai Naina Mohamed Salam, Sirajudeen Tengku Din, Tengku Ahmad Damitri Al-Astani A preliminary study on the effects of Stingless Bee Honey (SBH) on fasting blood glucose in Streptozotocin (STZ)-Induced diabetic rat models |
description |
Diabetes is a metabolic disorder characterized by hyperglycemia due to defects in insulin secretion, insulin action, or both. SBH has good antihyperglycemic potential and has traditionally been used as an alternative treatment for diabetes mellitus (DM). Since the role of SBH in glucose control is still unclear in animal and human studies, the present study was designed to evaluate the antihyperglycemic effects of SBH in streptozotocin-induced diabetic rat models. Fifteen Sprague-Dawley rats (200-250 g) were equally divided into five groups, the first group being a normal (non-diabetic) rat and the other four groups being diabetic. The normal and untreated diabetic groups received normal saline while the other diabetic groups were treated with SBH (2 g/kg body weight), metformin (MET /250 mg/kg body weight) and SBH + MET respectively.The treatment was given within 12 days. Fasting blood glucose (FBG) was measured at baseline and every two weeks thereafter. On days 7 and 12, SBH significantly lowered FBG, comparable to the normal group (p<0.05). In the group treated with MET and the combination of SBH-MET, FBG improved only on the 12th day of treatment (p<0.05). The results show that a single SBH treatment is effective in lowering blood glucose levels. Thus, SBH could be of great value in the treatment of diabetes in humans |
format |
Article |
author |
Ismail, Anis Farihan Mohd Nasir, Suriati Tuan Ismail, Tuan Salwani Wan Ahmad, Wan Amir Nizam Wan Abdul Rahman, Wan Faiziah Kuttulebbai Naina Mohamed Salam, Sirajudeen Tengku Din, Tengku Ahmad Damitri Al-Astani |
author_facet |
Ismail, Anis Farihan Mohd Nasir, Suriati Tuan Ismail, Tuan Salwani Wan Ahmad, Wan Amir Nizam Wan Abdul Rahman, Wan Faiziah Kuttulebbai Naina Mohamed Salam, Sirajudeen Tengku Din, Tengku Ahmad Damitri Al-Astani |
author_sort |
Ismail, Anis Farihan |
title |
A preliminary study on the effects of Stingless Bee Honey (SBH) on fasting blood glucose in Streptozotocin (STZ)-Induced diabetic rat models |
title_short |
A preliminary study on the effects of Stingless Bee Honey (SBH) on fasting blood glucose in Streptozotocin (STZ)-Induced diabetic rat models |
title_full |
A preliminary study on the effects of Stingless Bee Honey (SBH) on fasting blood glucose in Streptozotocin (STZ)-Induced diabetic rat models |
title_fullStr |
A preliminary study on the effects of Stingless Bee Honey (SBH) on fasting blood glucose in Streptozotocin (STZ)-Induced diabetic rat models |
title_full_unstemmed |
A preliminary study on the effects of Stingless Bee Honey (SBH) on fasting blood glucose in Streptozotocin (STZ)-Induced diabetic rat models |
title_sort |
preliminary study on the effects of stingless bee honey (sbh) on fasting blood glucose in streptozotocin (stz)-induced diabetic rat models |
publisher |
Malaysian Society of Applied Biology |
publishDate |
2021 |
url |
http://irep.iium.edu.my/95752/1/95752-A%20preliminary%20study%20on%20the%20effects%20of%20Stingless%20Bee%20Honey.pdf http://irep.iium.edu.my/95752/ https://jms.mabjournal.com/index.php/mab |
_version_ |
1720979931858468864 |
score |
13.188451 |