Effects of nicotine on Schizophrenia and antipsychotic medications: a systematic review
Majority people with schizophrenia who smoke cigarettes, tend to be heavy smokers than other psychiatric patients and general population. Nicotine is one of the main components of cigarettes that can produce nicotinic interactions with antipsychotic drugs. Nicotine can also alleviate psychotic s...
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Main Authors: | , |
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Format: | Article |
Language: | English |
Published: |
Malaysian Psychiatric Association
2018
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Subjects: | |
Online Access: | http://irep.iium.edu.my/95593/1/95593_Effects%20of%20nicotine%20on%20Schizophrenia.pdf http://irep.iium.edu.my/95593/ https://www.mjpsychiatry.org/index.php/mjp/article/view/471/355 |
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Summary: | Majority people with schizophrenia who smoke cigarettes, tend
to be heavy smokers than other psychiatric patients and general population.
Nicotine is one of the main components of cigarettes that can produce
nicotinic interactions with antipsychotic drugs. Nicotine can also alleviate
psychotic symptoms of schizophrenia. Aim: The objective for this systematic
review is to examine the effects of nicotine and nicotine-based products in the
treatment of schizophrenia, in comparison with placebo, no treatment or
antipsychotic medication. Results: All studies comparing nicotine or other
related products as the only treatment or adjunctive treatment for
schizophrenia patients excluding the animal studies and case studies are
reviewed. The use of traditional or known as typical antipsychotics may
cause the patients to smoke frequently while patients taking atypical
antipsychotics may smoke less. Patients who smoke may metabolize
antipsychotics faster than non-smoking patients. There is less report related
to smoking cessation among the schizophrenia patients. Conclusion:
Neurobiological and psychosocial factors reinforce the high use of nicotine by
patients with schizophrenia. Prior to smoking cessation implementation, it is
crucial to understand on the ways and reasons for schizophrenia patients to
consume nicotine for self-medicate symptoms which may lead to the
development of new treatments for schizophrenia and nicotine dependence. |
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