Curcumin gum Arabic nanoparticles demonstrate potent antioxidant and cytotoxic properties in human cancer cells

• Main Authors: Hassani, Abdelkader, Hussain, Siti Aslina, Al-Qubaisi, Mothanna Sadiq, Belfar, Mohamed Lakhder, Belkhalfa, Hakim, Enezei, Hamid Hammad, Zentou, Hamid, Ibrahim, Wisam Nabeel, Doolaanea, Abd Almonem
• Format: Article
• Language: English; English; English
• Published: Tech Science Press 2021
• Subjects: RS Pharmacy and materia medica
• Online Access: http://irep.iium.edu.my/95074/13/95074_Curcumin%20gum%20Arabic%20nanoparticles%20demonstrate_WoS.pdf; http://irep.iium.edu.my/95074/14/95074_Curcumin%20gum%20Arabic%20nanoparticles%20demonstrate_SCOPUS.pdf; http://irep.iium.edu.my/95074/15/95074_Curcumin%20gum%20Arabic%20nanoparticles%20demonstrate.pdf; http://irep.iium.edu.my/95074/; https://www.techscience.com/biocell/v46n3/45624/pdf

The main purpose of the study was to enhance the stability and therapeutic effects of Curcumin (Cur) through nanoformulation with gum Arabic (GA) as a coating agent through an efficient synthetic approach. The antioxidant properties of the developed nanoparticles (Cur/GANPs) were assessed through several in vitro assays, such as β-carotene bleaching activity, DPPH, and nitric oxide scavenging activities in addition to evaluating its inhibitory activity on angiotensin-converting enzyme (ACE). The cytotoxicity of Cur/GANPs was evaluated in vitro using different types of human cancer cells including breast cancer (MCF7, MDA-MB231), liver cancer (HepG2), and colon cancer (HT29) cells. The prepared particles displayed an elliptical shape with a size ranging between 20–260 nm and a potential difference of –15 mV. The Cur/GANPs exhibited significant antioxidant activity compared to free curcumin when using concentrations between 31.5 and 500 µg/mL. The Cur/GANPs also had inhibited the growth of all cancer cell lines in a proportional trend with concentrations used. Hence, the encapsulation with gum Arabic has augmented the antioxidant and anti-neoplastic effects of Curcumin. Therefore, Cur/GANPs may have effective therapeutic properties in diseases attributed to oxidative stress like cancer and hypertension.