Influence of nanoparticles surface coating on physicochemical properties for CRISPR gene delivery

• Main Authors: Alallam, Batoul, Doolaanea, Abd Almonem, Oo, May Kyaw, Mohd Nasir, Mohd Hamzah, Muhammad, Taher
• Format: Article
• Language: English
• Published: ScienceDirect 2021
• Subjects: Q Science (General)
• Online Access: http://irep.iium.edu.my/93190/7/93190_Influence%20of%20nanoparticles%20surface%20coating.pdf; http://irep.iium.edu.my/93190/; https://www.sciencedirect.com/science/article/abs/pii/S1773224721005906?via%3Dihub; https://doi.org/10.1016/j.jddst.2021.102910

CRISPR is a powerful gene editing tool, but its non-viral delivery approaches are still limited due to low efficacy. To improve the efficacy of plasmid loaded alginate nanoparticles, three different polymer coating, chitosan, gum Arabic and PEG were applied and studied in comparison. The surface coa...