Antibacterial activity of benzoyl and halobenzoyl thiourea bearing α- and β-alanine
Antibacterial activity of synthetically synthesized benzoyl thiourea and halobenzoyl thiourea bearing α-alanine and β-alanine compounds were investigated against gram-positive bacteria (Staphylococcus aureus and Bacillus subtilis) and gram-negative bacteria (Esherichia coli). The study of antibacter...
Saved in:
Main Authors: | , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Zibeline International Publishing
2021
|
Subjects: | |
Online Access: | http://irep.iium.edu.my/93002/7/93002_Antibacterial%20activity%20of%20benzoyl.pdf http://irep.iium.edu.my/93002/ https://jcleanwas.com/download/1454/ http://doi.org/10.26480/jcleanwas.01.2021.35.38 |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
id |
my.iium.irep.93002 |
---|---|
record_format |
dspace |
spelling |
my.iium.irep.930022021-10-13T03:28:35Z http://irep.iium.edu.my/93002/ Antibacterial activity of benzoyl and halobenzoyl thiourea bearing α- and β-alanine Ibrahim, Maizatul Akma Husin, Atiyah Ngah, Nurziana Zakaria, Nor Hafizah Q Science (General) QD Chemistry QR Microbiology R Medicine (General) Antibacterial activity of synthetically synthesized benzoyl thiourea and halobenzoyl thiourea bearing α-alanine and β-alanine compounds were investigated against gram-positive bacteria (Staphylococcus aureus and Bacillus subtilis) and gram-negative bacteria (Esherichia coli). The study of antibacterial activity of the compounds was conducted by using the disc diffusion method and minimal inhibitory concentration (MIC) as well as minimal bactericidal concentration (MBC). The results indicate that 4-fluorobenzoylthiourea α-alanine, benzoylthiourea α-alanine, 4-fluorobenzoylthiourea β-alanine, 4-chlorobenzoylthiourea β-alanine, 4-bromobenzoylthiourea β-alanine, and benzoylthiourea β-alanine possess weak to strong antibacterial activity on all of tested bacteria. The strongest antibacterial activity was found in the 4-fluorobenzoylthiourea α-alanine, whereas the weakest antibacterial activity was exhibited in 4-fluorobenzoylthiourea β-alanine. S. aureus was found the most susceptible toward these thiourea derivatives, indicating bactericidal activity against the bacteria. Zibeline International Publishing 2021-06-28 Article PeerReviewed application/pdf en http://irep.iium.edu.my/93002/7/93002_Antibacterial%20activity%20of%20benzoyl.pdf Ibrahim, Maizatul Akma and Husin, Atiyah and Ngah, Nurziana and Zakaria, Nor Hafizah (2021) Antibacterial activity of benzoyl and halobenzoyl thiourea bearing α- and β-alanine. Journal Clean WAS (JCleanWAS), 5 (1). pp. 35-38. ISSN 2521-0912 E-ISSN 2521-0513 https://jcleanwas.com/download/1454/ http://doi.org/10.26480/jcleanwas.01.2021.35.38 |
institution |
Universiti Islam Antarabangsa Malaysia |
building |
IIUM Library |
collection |
Institutional Repository |
continent |
Asia |
country |
Malaysia |
content_provider |
International Islamic University Malaysia |
content_source |
IIUM Repository (IREP) |
url_provider |
http://irep.iium.edu.my/ |
language |
English |
topic |
Q Science (General) QD Chemistry QR Microbiology R Medicine (General) |
spellingShingle |
Q Science (General) QD Chemistry QR Microbiology R Medicine (General) Ibrahim, Maizatul Akma Husin, Atiyah Ngah, Nurziana Zakaria, Nor Hafizah Antibacterial activity of benzoyl and halobenzoyl thiourea bearing α- and β-alanine |
description |
Antibacterial activity of synthetically synthesized benzoyl thiourea and halobenzoyl thiourea bearing α-alanine and β-alanine compounds were investigated against gram-positive bacteria (Staphylococcus aureus and Bacillus subtilis) and gram-negative bacteria (Esherichia coli). The study of antibacterial activity of the compounds was conducted by using the disc diffusion method and minimal inhibitory concentration (MIC) as well as minimal bactericidal concentration (MBC). The results indicate that 4-fluorobenzoylthiourea α-alanine, benzoylthiourea α-alanine, 4-fluorobenzoylthiourea β-alanine, 4-chlorobenzoylthiourea β-alanine, 4-bromobenzoylthiourea β-alanine, and benzoylthiourea β-alanine possess weak to strong antibacterial activity on all of tested bacteria. The strongest antibacterial activity was found in the 4-fluorobenzoylthiourea α-alanine, whereas the weakest antibacterial activity was exhibited in 4-fluorobenzoylthiourea β-alanine. S. aureus was found the most susceptible toward these thiourea derivatives, indicating bactericidal activity against the bacteria. |
format |
Article |
author |
Ibrahim, Maizatul Akma Husin, Atiyah Ngah, Nurziana Zakaria, Nor Hafizah |
author_facet |
Ibrahim, Maizatul Akma Husin, Atiyah Ngah, Nurziana Zakaria, Nor Hafizah |
author_sort |
Ibrahim, Maizatul Akma |
title |
Antibacterial activity of benzoyl and halobenzoyl thiourea bearing α- and β-alanine |
title_short |
Antibacterial activity of benzoyl and halobenzoyl thiourea bearing α- and β-alanine |
title_full |
Antibacterial activity of benzoyl and halobenzoyl thiourea bearing α- and β-alanine |
title_fullStr |
Antibacterial activity of benzoyl and halobenzoyl thiourea bearing α- and β-alanine |
title_full_unstemmed |
Antibacterial activity of benzoyl and halobenzoyl thiourea bearing α- and β-alanine |
title_sort |
antibacterial activity of benzoyl and halobenzoyl thiourea bearing α- and β-alanine |
publisher |
Zibeline International Publishing |
publishDate |
2021 |
url |
http://irep.iium.edu.my/93002/7/93002_Antibacterial%20activity%20of%20benzoyl.pdf http://irep.iium.edu.my/93002/ https://jcleanwas.com/download/1454/ http://doi.org/10.26480/jcleanwas.01.2021.35.38 |
_version_ |
1715189401253838848 |
score |
13.160551 |