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Discovery of new inhibitor for the Protein Arginine Deiminase Type 4 (PAD4) by Rational Design of α-Enolase-derived Peptides

Rheumatoid arthritis (RA) is an inflammatory autoimmune disease affecting about 0.5–1.0% of the world population. Protein arginine deiminase type 4 (PAD4) is believed to be responsible for the occurrence of RA by catalyzing citrullination of proteins. The citrullinated proteins act as autoantigens b...

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Bibliographic Details
Main Authors: Ahmad Nadzirin, Izzuddin, Chor, Adam Leow Thean, Salleh, Abu Bakar, Abdul Rahman, Mohd Basyaruddin, Tejo, Bimo Ario
Format: Article
Language:English
English
Published: Elsevier Ltd. 2021
Subjects:
QD Chemistry
RM Therapeutics. Pharmacology
RM300 Drugs and their action
Online Access:http://irep.iium.edu.my/92776/7/92776_Discovery%20of%20new%20inhibitor%20for%20the%20Protein%20Arginine%20Deiminase%20Type%204%20%28PAD4%29.pdf
http://irep.iium.edu.my/92776/8/92776_Discovery%20of%20new%20inhibitor%20for%20the%20Protein%20Arginine%20Deiminase%20Type%204%20%28PAD4%29_Scopus.pdf
http://irep.iium.edu.my/92776/
https://www.sciencedirect.com/science/article/abs/pii/S1476927121000542
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http://irep.iium.edu.my/92776/7/92776_Discovery%20of%20new%20inhibitor%20for%20the%20Protein%20Arginine%20Deiminase%20Type%204%20%28PAD4%29.pdf
http://irep.iium.edu.my/92776/8/92776_Discovery%20of%20new%20inhibitor%20for%20the%20Protein%20Arginine%20Deiminase%20Type%204%20%28PAD4%29_Scopus.pdf
http://irep.iium.edu.my/92776/
https://www.sciencedirect.com/science/article/abs/pii/S1476927121000542

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