Loss of add1 methylation adds on blood pressure in young adults
Objective: To investigate the association between alpha-Adducin (ADD1) methylation and blood pressure in young adults with essential hypertension. Design and method: A total of 160 subjects (80 normotensive and 80 incident hypertensive) aged between 18 to 45 years from Kuantan, Pahang were includ...
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Wolters Kluwer Health
2021
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my.iium.irep.908512021-07-16T02:14:12Z http://irep.iium.edu.my/90851/ Loss of add1 methylation adds on blood pressure in young adults Wan Omar, Wan Fatein Nabeila A.Talib, Norlelawati Ab Rahman, Jamalludin Mohd Shah, Azarisman Shah Abdullah, Aszrin QP Physiology RB Pathology RC667 Specialties of Internal Medicine-Diseases of Circulatory (Cardiovascular) System Objective: To investigate the association between alpha-Adducin (ADD1) methylation and blood pressure in young adults with essential hypertension. Design and method: A total of 160 subjects (80 normotensive and 80 incident hypertensive) aged between 18 to 45 years from Kuantan, Pahang were included in a cross-sectional study by purposive sampling. They were assessed for ADD1 methylation in peripheral blood using MethyLight assay. Anthropometric measurements and biochemical parameters were also examined. Results: ADD1 methylation was inversely correlated with systolic (p = 0.006, r = –0.240), diastolic (p = 0.001, r = –0.281) and mean arterial pressures (p = 0.002, r = –0.270). Hypertensive subjects had significantly higher ADD1 methylation than normotensive control (p = 0.005). After adjusting for other relevant covariates (age, body mass index, HbA1c, high-sensitivity C-reactive protein and low density lipoprotein cholesterol), ADD1 methylation remained a significant predictor for hypertension in young adults (p = 0.020) Conclusions: ADD1 methylation is a significant predictor of hypertension in young adults. ADD1 methylation could serve as a future preventive and therapeutic target for hypertension and related cardiovascular disease. Wolters Kluwer Health 2021-04 Article PeerReviewed application/pdf en http://irep.iium.edu.my/90851/8/90851_Loss%20of%20add1%20methylation%20adds.pdf application/pdf en http://irep.iium.edu.my/90851/9/90851_Loss%20of%20add1%20methylation%20adds%20on%20blood%20pressure.pdf Wan Omar, Wan Fatein Nabeila and A.Talib, Norlelawati and Ab Rahman, Jamalludin and Mohd Shah, Azarisman Shah and Abdullah, Aszrin (2021) Loss of add1 methylation adds on blood pressure in young adults. Journal of Hypertension, 39. e259. ISSN 0263-6352 E-ISSN 1473-5598 https://journals.lww.com/jhypertension/Abstract/2021/04001/LOSS_OF_ADD1_METHYLATION_ADDS_ON_BLOOD_PRESSURE_IN.763.aspx 10.1097/01.hjh.0000747408.35123.b3 |
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QP Physiology RB Pathology RC667 Specialties of Internal Medicine-Diseases of Circulatory (Cardiovascular) System Wan Omar, Wan Fatein Nabeila A.Talib, Norlelawati Ab Rahman, Jamalludin Mohd Shah, Azarisman Shah Abdullah, Aszrin Loss of add1 methylation adds on blood pressure in young adults |
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Objective: To investigate the association between alpha-Adducin (ADD1) methylation and blood pressure in young adults with essential hypertension.
Design and method: A total of 160 subjects (80 normotensive and 80 incident hypertensive) aged between 18 to 45 years from Kuantan, Pahang were included in a cross-sectional study by purposive sampling. They were assessed for ADD1 methylation in peripheral blood using MethyLight assay. Anthropometric measurements and biochemical parameters were also examined.
Results: ADD1 methylation was inversely correlated with systolic (p = 0.006, r = –0.240), diastolic (p = 0.001, r = –0.281) and mean arterial pressures (p = 0.002, r = –0.270). Hypertensive subjects had significantly higher ADD1 methylation than normotensive control (p = 0.005). After adjusting for other relevant covariates (age, body mass index, HbA1c, high-sensitivity C-reactive protein and low density lipoprotein cholesterol), ADD1 methylation remained a significant predictor for hypertension in young adults (p = 0.020)
Conclusions: ADD1 methylation is a significant predictor of hypertension in young adults. ADD1 methylation could serve as a future preventive and therapeutic target for hypertension and related cardiovascular disease. |
format |
Article |
author |
Wan Omar, Wan Fatein Nabeila A.Talib, Norlelawati Ab Rahman, Jamalludin Mohd Shah, Azarisman Shah Abdullah, Aszrin |
author_facet |
Wan Omar, Wan Fatein Nabeila A.Talib, Norlelawati Ab Rahman, Jamalludin Mohd Shah, Azarisman Shah Abdullah, Aszrin |
author_sort |
Wan Omar, Wan Fatein Nabeila |
title |
Loss of add1 methylation adds on blood pressure in young adults |
title_short |
Loss of add1 methylation adds on blood pressure in young adults |
title_full |
Loss of add1 methylation adds on blood pressure in young adults |
title_fullStr |
Loss of add1 methylation adds on blood pressure in young adults |
title_full_unstemmed |
Loss of add1 methylation adds on blood pressure in young adults |
title_sort |
loss of add1 methylation adds on blood pressure in young adults |
publisher |
Wolters Kluwer Health |
publishDate |
2021 |
url |
http://irep.iium.edu.my/90851/8/90851_Loss%20of%20add1%20methylation%20adds.pdf http://irep.iium.edu.my/90851/9/90851_Loss%20of%20add1%20methylation%20adds%20on%20blood%20pressure.pdf http://irep.iium.edu.my/90851/ https://journals.lww.com/jhypertension/Abstract/2021/04001/LOSS_OF_ADD1_METHYLATION_ADDS_ON_BLOOD_PRESSURE_IN.763.aspx |
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13.211869 |