Loss of add1 methylation adds on blood pressure in young adults

Objective: To investigate the association between alpha-Adducin (ADD1) methylation and blood pressure in young adults with essential hypertension. Design and method: A total of 160 subjects (80 normotensive and 80 incident hypertensive) aged between 18 to 45 years from Kuantan, Pahang were includ...

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Main Authors: Wan Omar, Wan Fatein Nabeila, A.Talib, Norlelawati, Ab Rahman, Jamalludin, Mohd Shah, Azarisman Shah, Abdullah, Aszrin
Format: Article
Language:English
English
Published: Wolters Kluwer Health 2021
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Online Access:http://irep.iium.edu.my/90851/8/90851_Loss%20of%20add1%20methylation%20adds.pdf
http://irep.iium.edu.my/90851/9/90851_Loss%20of%20add1%20methylation%20adds%20on%20blood%20pressure.pdf
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https://journals.lww.com/jhypertension/Abstract/2021/04001/LOSS_OF_ADD1_METHYLATION_ADDS_ON_BLOOD_PRESSURE_IN.763.aspx
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spelling my.iium.irep.908512021-07-16T02:14:12Z http://irep.iium.edu.my/90851/ Loss of add1 methylation adds on blood pressure in young adults Wan Omar, Wan Fatein Nabeila A.Talib, Norlelawati Ab Rahman, Jamalludin Mohd Shah, Azarisman Shah Abdullah, Aszrin QP Physiology RB Pathology RC667 Specialties of Internal Medicine-Diseases of Circulatory (Cardiovascular) System Objective: To investigate the association between alpha-Adducin (ADD1) methylation and blood pressure in young adults with essential hypertension. Design and method: A total of 160 subjects (80 normotensive and 80 incident hypertensive) aged between 18 to 45 years from Kuantan, Pahang were included in a cross-sectional study by purposive sampling. They were assessed for ADD1 methylation in peripheral blood using MethyLight assay. Anthropometric measurements and biochemical parameters were also examined. Results: ADD1 methylation was inversely correlated with systolic (p = 0.006, r = –0.240), diastolic (p = 0.001, r = –0.281) and mean arterial pressures (p = 0.002, r = –0.270). Hypertensive subjects had significantly higher ADD1 methylation than normotensive control (p = 0.005). After adjusting for other relevant covariates (age, body mass index, HbA1c, high-sensitivity C-reactive protein and low density lipoprotein cholesterol), ADD1 methylation remained a significant predictor for hypertension in young adults (p = 0.020) Conclusions: ADD1 methylation is a significant predictor of hypertension in young adults. ADD1 methylation could serve as a future preventive and therapeutic target for hypertension and related cardiovascular disease. Wolters Kluwer Health 2021-04 Article PeerReviewed application/pdf en http://irep.iium.edu.my/90851/8/90851_Loss%20of%20add1%20methylation%20adds.pdf application/pdf en http://irep.iium.edu.my/90851/9/90851_Loss%20of%20add1%20methylation%20adds%20on%20blood%20pressure.pdf Wan Omar, Wan Fatein Nabeila and A.Talib, Norlelawati and Ab Rahman, Jamalludin and Mohd Shah, Azarisman Shah and Abdullah, Aszrin (2021) Loss of add1 methylation adds on blood pressure in young adults. Journal of Hypertension, 39. e259. ISSN 0263-6352 E-ISSN 1473-5598 https://journals.lww.com/jhypertension/Abstract/2021/04001/LOSS_OF_ADD1_METHYLATION_ADDS_ON_BLOOD_PRESSURE_IN.763.aspx 10.1097/01.hjh.0000747408.35123.b3
institution Universiti Islam Antarabangsa Malaysia
building IIUM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider International Islamic University Malaysia
content_source IIUM Repository (IREP)
url_provider http://irep.iium.edu.my/
language English
English
topic QP Physiology
RB Pathology
RC667 Specialties of Internal Medicine-Diseases of Circulatory (Cardiovascular) System
spellingShingle QP Physiology
RB Pathology
RC667 Specialties of Internal Medicine-Diseases of Circulatory (Cardiovascular) System
Wan Omar, Wan Fatein Nabeila
A.Talib, Norlelawati
Ab Rahman, Jamalludin
Mohd Shah, Azarisman Shah
Abdullah, Aszrin
Loss of add1 methylation adds on blood pressure in young adults
description Objective: To investigate the association between alpha-Adducin (ADD1) methylation and blood pressure in young adults with essential hypertension. Design and method: A total of 160 subjects (80 normotensive and 80 incident hypertensive) aged between 18 to 45 years from Kuantan, Pahang were included in a cross-sectional study by purposive sampling. They were assessed for ADD1 methylation in peripheral blood using MethyLight assay. Anthropometric measurements and biochemical parameters were also examined. Results: ADD1 methylation was inversely correlated with systolic (p = 0.006, r = –0.240), diastolic (p = 0.001, r = –0.281) and mean arterial pressures (p = 0.002, r = –0.270). Hypertensive subjects had significantly higher ADD1 methylation than normotensive control (p = 0.005). After adjusting for other relevant covariates (age, body mass index, HbA1c, high-sensitivity C-reactive protein and low density lipoprotein cholesterol), ADD1 methylation remained a significant predictor for hypertension in young adults (p = 0.020) Conclusions: ADD1 methylation is a significant predictor of hypertension in young adults. ADD1 methylation could serve as a future preventive and therapeutic target for hypertension and related cardiovascular disease.
format Article
author Wan Omar, Wan Fatein Nabeila
A.Talib, Norlelawati
Ab Rahman, Jamalludin
Mohd Shah, Azarisman Shah
Abdullah, Aszrin
author_facet Wan Omar, Wan Fatein Nabeila
A.Talib, Norlelawati
Ab Rahman, Jamalludin
Mohd Shah, Azarisman Shah
Abdullah, Aszrin
author_sort Wan Omar, Wan Fatein Nabeila
title Loss of add1 methylation adds on blood pressure in young adults
title_short Loss of add1 methylation adds on blood pressure in young adults
title_full Loss of add1 methylation adds on blood pressure in young adults
title_fullStr Loss of add1 methylation adds on blood pressure in young adults
title_full_unstemmed Loss of add1 methylation adds on blood pressure in young adults
title_sort loss of add1 methylation adds on blood pressure in young adults
publisher Wolters Kluwer Health
publishDate 2021
url http://irep.iium.edu.my/90851/8/90851_Loss%20of%20add1%20methylation%20adds.pdf
http://irep.iium.edu.my/90851/9/90851_Loss%20of%20add1%20methylation%20adds%20on%20blood%20pressure.pdf
http://irep.iium.edu.my/90851/
https://journals.lww.com/jhypertension/Abstract/2021/04001/LOSS_OF_ADD1_METHYLATION_ADDS_ON_BLOOD_PRESSURE_IN.763.aspx
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score 13.211869