Mode of action of 5-acetyl-4-methylthiazole derivatives as antimicrobial agents
Thiazole derivatives have been widely known to possess antimicrobial behaviour. The purpose of this study is to investigate the mode of antimicrobial actions of synthesised thiazole compounds on Gram-positive bacteria (Staphylococcus aureus), Gram-negative bacteria (Salmonella typhimurium), and fung...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English English |
| Published: |
Faculty of Science and Technology, Universiti Kebangsaan Malaysia
2021
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| Subjects: | |
| Online Access: | http://irep.iium.edu.my/90572/7/90572_Mode%20of%20action%20of%205-acetyl-4-methylthiazole%20derivatives%20as%20antimicrobial%20agents.pdf http://irep.iium.edu.my/90572/8/90572_Mode%20of%20action%20of%205-acetyl-4-methylthiazole%20derivatives_Scopus.pdf http://irep.iium.edu.my/90572/ https://mjas.analis.com.my/mjas/v25_n2/pdf/Iswatun_25_2_14.pdf |
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| Summary: | Thiazole derivatives have been widely known to possess antimicrobial behaviour. The purpose of this study is to investigate the mode of antimicrobial actions of synthesised thiazole compounds on Gram-positive bacteria (Staphylococcus aureus), Gram-negative bacteria (Salmonella typhimurium), and fungus (Candida albicans). Three synthesised thiazole compounds namely 5-acetyl-4-methyl-2-(3,4-dichloroaniline)-1,3-thiazole (T1), 5-acetyl-4-methyl-2-(4-aminophenol)-1,3-thiazole (T2), and 5-acetyl-4-methyl-2-(methyl-4-aminobenzoate)-1,3-thiazole (T3) were evaluated in the mode of action assays such as salt tolerance, time-killing, crystal violet and leakage 260/280 nm absorbing materials. The result showed that the T3 compound exhibited the best performance for all tested assays at a concentration equal to 4 × MIC compared to T1 and T2. |
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