Epigenetic insights and potential modifiers as therapeutic targets in β–thalassemia

• Main Authors: Zakaria, Nur Atikah, Islam, Md Asiful, Abdullah, Wan Zaidah, Bahar, Rosnah, Mohamed Yusoff, Abdul Aziz, Abdul Wahab, Ridhwan, Shamsuddin, Shaharum, Johan, Muhammad Farid
• Format: Article
• Language: English; English
• Published: Multidisciplinary Digital Publishing Institute (MDPI) 2021
• Subjects: RB Pathology
• Online Access: http://irep.iium.edu.my/90063/7/90063_Epigenetic%20insights%20and%20potential%20modifiers%20as%20therapeutic%20targets%20in%20%CE%B2%E2%80%93thalassemia_SCOPUS.pdf; http://irep.iium.edu.my/90063/13/90063_Epigenetic%20insights%20and%20potential%20modifiers%20as%20therapeutic%20targets%20in%20%CE%B2%E2%80%93thalassemia.pdf; http://irep.iium.edu.my/90063/; https://www.mdpi.com/2218-273X/11/5/755; https://doi.org/10.3390/biom11050755

Thalassemia, an inherited quantitative globin disorder, consists of two types, α– and β–thalassemia. β–thalassemia is a heterogeneous disease that can be asymptomatic, mild, or even severe. Considerable research has focused on investigating its underlying etiology. These studies found that DNA hypom...