Na+ entry through heteromeric TRPC4/C1 channels mediates (−)Englerin A-induced cytotoxicity in synovial sarcoma cells

• Main Authors: Muraki, Katsuhiko, Ohnishi, Kaori, Takezawa, Akiho, Suzuki, Hiroka, Hatano, Noriyuki, Muraki, Yukiko, Hamzah, Nurasyikin, Foster, Richard, Waldmann, Herbert, Nussbaumer, Peter, Christmann, Mathias, Bon, Robin S., Beech, David J.
• Format: Article
• Language: English
• Published: 2017
• Subjects: RM Therapeutics. Pharmacology
• Online Access: http://irep.iium.edu.my/90011/2/s41598-017-17303-3.pdf; http://irep.iium.edu.my/90011/; http://doi.org/10.1038/s41598-017-17303-3

The sesquiterpene (−)Englerin A (EA) is an organic compound from the plant Phyllanthus engleri which acts via heteromeric TRPC4/C1 channels to cause cytotoxicity in some types of cancer cell but not normal cells. Here we identified selective cytotoxicity of EA in human synovial sarcoma cells (SW982...