The intraperitoneal ondansetron for postoperative pain management following laparoscopic cholecystectomy: A proof-of-concept, double-blind, placebo-controlled trial

• Main Authors: Abdelaziz, Doaa, Boraii, Sherif, Cheema, Ejaz, Elnaem, Mohamed Hassan Abdelaziz, Omar, Tamer, Abdelrauof, Amr, Mansour, Noha
• Format: Article
• Language: English; English; English
• Published: Elsevier 2021
• Subjects: RC803 Specialties of Internal Medicine-Diseases of The Digestive System. Gastroenterology; RD81 Anesthesiology; RS Pharmacy and materia medica
• Online Access: http://irep.iium.edu.my/89991/7/89991_The%20intraperitoneal%20ondansetron%20for%20postoperative%20pain%20management.pdf; http://irep.iium.edu.my/89991/13/89991_The%20intraperitoneal%20ondansetron%20for%20postoperative_SCOPUS.pdf; http://irep.iium.edu.my/89991/14/89991_The%20intraperitoneal%20ondansetron%20for%20postoperative_WOS.pdf; http://irep.iium.edu.my/89991/; https://www.sciencedirect.com/science/article/pii/S0753332221005072?via%3Dihub#!; https://doi.org/10.1016/j.biopha.2021.111725

Background Pain after laparoscopic cholecystectomy remains a major challenge. Ondansetron blocks sodium channels and may have local anesthetic properties. Aims To investigate the effect of intraperitoneal administration of ondansetron for postoperative pain management as an adjuvant to intraven...