Identification of alkaloid compounds arborinine and graveoline from Ruta angustifolia (L.) Pers. for their antifungal potential against isocitrate lyase (ICL1) gene of Candida albicans

• Main Authors: Mohd Kamal, Laina Zarisa, Ahmed Adam, Mowaffaq Adam, Mohd. Shahpudin, Siti Nurfatimah, Shuib, Ahmad Naqeeb, Sandai, Rosline, Mohd Hassan, Norazian, Tabana, Yasser, Basri, Dayang Fredalina, Lung Than, Leslie Thian, Sandai, Doblin
• Format: Article
• Language: English; English
• Published: Springer Science and Business Media B.V. 2021
• Subjects: QR Microbiology; RS403 Materia Medica-Pharmaceutical Chemistry
• Online Access: http://irep.iium.edu.my/88578/7/88578_Identification%20of%20alkaloid%20compounds%20arborinine.pdf; http://irep.iium.edu.my/88578/8/88578_Identification%20of%20alkaloid%20compounds%20arbor_Scopus.pdf; http://irep.iium.edu.my/88578/; https://doi.org/10.1007/s11046-020-00523-z(0123456789().,-volV()0123456789().,-volV)

Candida albicans has been reported glob- ally as the most widespread pathogenic species con- tributing candidiasis from superficial to systemic infections in immunocompromised individuals. Their metabolic adaptation depends on glyoxylate cycle to survive in nutrient-limited host. The long term usage...