Alzheimer's disease: from bench side to bed side

• Main Authors: Mohamed, Wael Mohamed Yousef, Yoon, Chee Kok, Doolaanea, Abd Almonem
• Format: Conference or Workshop Item
• Language: English; English; English; English; English
• Published: 2020
• Subjects: RM Therapeutics. Pharmacology; RS Pharmacy and materia medica
• Online Access: http://irep.iium.edu.my/88240/2/BNC%202020%20Hi5%202020%20Dr%20Abd%20Almonem.pdf; http://irep.iium.edu.my/88240/14/Hi5%202020_Tentative_Final_29%20NOV%202020.pdf; http://irep.iium.edu.my/88240/15/E%20PROGRAM%20BOOK%20BNC%20Hi5%20Retreat%202020.pdf; http://irep.iium.edu.my/88240/17/Translational%20Forum%20Invitation%20Letter_%20Dr%20Wael%20et%20al.pdf; http://irep.iium.edu.my/88240/16/01%20Cert_Hi5_Attendance.pdf; http://irep.iium.edu.my/88240/

Drug systematic administration to brain is challenged by blood–brain barrier (BBB). Only small lipophilic drugs cross BBB. Nearly 100% of biologics cannot cross BBB. Biologics composed 33% of FDA-approved drugs in 2019. Nanoparticles were used to cross BBB after suitable surface modification with molecules to recognize receptors on BBB.