In silico mutation on a mutant lipase from Acinetobacter haemolyticus towards enhancing alkaline stability

• Main Authors: Khairul Anuar, Nurul Fatin Syamimi, Abdul Wahab, Roswanira, Huyop, Fahrul Zaman, Abd Halim, Khairul Bariyyah, Abdul Hamid, Azzmer Azzar
• Format: Article
• Language: English; English; English
• Published: Taylor and Francis Ltd. 2020
• Subjects: QD Chemistry
• Online Access: http://irep.iium.edu.my/88006/1/88006_In%20silico%20mutation%20on%20a%20mutant%20lipase.pdf; http://irep.iium.edu.my/88006/2/88006_In%20silico%20mutation%20on%20a%20mutant%20lipase_SCOPUS.pdf; http://irep.iium.edu.my/88006/3/88006_In%20silico%20mutation%20on%20a%20mutant%20lipase_WoS.pdf; http://irep.iium.edu.my/88006/; https://www.tandfonline.com/doi/full/10.1080/07391102.2019.1683074

Alkaline-stable lipases are highly valuable biocatalysts that catalyze reactions under highly basic conditions. Herein, computational predictions of lipase from Acinetobacter haemolyticus and its mutant, Mut-LipKV1 was performed to identify functionally relevant mutations that enhance pH performance...