Horseshoe crab genomes reveal evolutionary fates of genes and microRNAs after three rounds (3R) of whole genome duplication in invertebrates
Whole genome duplication (WGD) has occurred in relatively few sexually reproducing invertebrates. Consequently, the WGD that occurred in the common ancestor of horseshoe crabs ~135 million years ago provides a rare opportunity to decipher the evolutionary consequences of a duplicated invertebrate...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English English English |
| Published: |
Nature Research
2021
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| Subjects: | |
| Online Access: | http://irep.iium.edu.my/87972/7/87972%20Horseshoe%20crab%20genomes%20reveal%20the%20evolution.pdf http://irep.iium.edu.my/87972/13/87972%20Horseshoe%20crab%20genomes%20reveal%20the%20evolution_scopus.pdf http://irep.iium.edu.my/87972/14/87972%20Horseshoe%20crab%20genomes%20reveal%20the%20evolution_wos.pdf http://irep.iium.edu.my/87972/ https://www.nature.com/articles/s42003-020-01637-2.pdf |
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| Summary: | Whole genome duplication (WGD) has occurred in relatively few sexually reproducing
invertebrates. Consequently, the WGD that occurred in the common ancestor of horseshoe
crabs ~135 million years ago provides a rare opportunity to decipher the evolutionary consequences of a duplicated invertebrate genome. Here, we present a high-quality genome
assembly for the mangrove horseshoe crab Carcinoscorpius rotundicauda (1.7 Gb, N50 = 90.2
Mb, with 89.8% sequences anchored to 16 pseudomolecules, 2n = 32), and a resequenced
genome of the tri-spine horseshoe crab Tachypleus tridentatus (1.7 Gb, N50 = 109.7 Mb).
Analyses of gene families, microRNAs, and synteny show that horseshoe crabs have
undergone three rounds (3R) of WGD. Comparison of C. rotundicauda and T. tridentatus
genomes from populations from several geographic locations further elucidates the diverse
fates of both coding and noncoding genes. Together, the present study represents a cornerstone for improving our understanding of invertebrate WGD events on the evolutionary
fates of genes and microRNAs, at both the individual and population level. We also provide
improved genomic resources for horseshoe crabs, of applied value for breeding programs and
conservation of this fascinating and unusual invertebrate lineage |
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