Alginate nanoformulation: influence of process and selected variables
Nanocarriers are defined as structures and devices that are constructed using nanomaterials which add functionality to the encapsulants. Being small in size and having a customized surface, improved solubility and multi-functionality, it is envisaged that nanoparticles will continue to create new...
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Format: | Article |
Language: | English English English |
Published: |
MDPI AG
2020
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Online Access: | http://irep.iium.edu.my/87927/1/87927_Alginate%20nanoformulation%20influence%20of%20process.pdf http://irep.iium.edu.my/87927/2/87927_Alginate%20nanoformulation%20influence%20of%20process_SCOPUS.pdf http://irep.iium.edu.my/87927/3/87927_Alginate%20nanoformulation%20influence%20of%20process_WoS.pdf http://irep.iium.edu.my/87927/ https://www.mdpi.com/1424-8247/13/11/335/htm |
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Summary: | Nanocarriers are defined as structures and devices that are constructed using nanomaterials
which add functionality to the encapsulants. Being small in size and having a customized surface,
improved solubility and multi-functionality, it is envisaged that nanoparticles will continue to create
new biomedical applications owing to their stability, solubility, and bioavailability, as well as controlled
release of drugs. The type and physiochemical as well as morphological attributes of nanoparticles
influence their interaction with living cells and determine the route of administration, clearance, as
well as related toxic effects. Over the past decades, biodegradable polymers such as polysaccharides
have drowned a great deal of attention in pharmaceutical industry with respect to designing of drug
delivery systems. On this note, biodegradable polymeric nanocarrier is deemed to control the release
of the drug, stabilize labile molecules from degradation and site-specific drug targeting, with the main
aim of reducing the dosing frequency and prolonging the therapeutic outcomes. Thus, it is essential
to select the appropriate biopolymer material, e.g., sodium alginate to formulate nanoparticles
for controlled drug delivery. Alginate has attracted considerable interest in pharmaceutical and
biomedical applications as a matrix material of nanocarriers due to its inherent biological properties,
including good biocompatibility and biodegradability. Various techniques have been adopted
to synthesize alginate nanoparticles in order to introduce more rational, coherent, efficient and
cost-effective properties. This review highlights the most used and recent manufacturing techniques
of alginate-based nanoparticulate delivery system, including emulsification/gelation complexation,
layer-by-layer, spray drying, electrospray and electrospinning methods. Besides, the effects of the
main processing and formulation parameters on alginate nanoparticles are also summarized |
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