Post-kala-azar dermal leishmaniasis with mucosal involvement: an unusual case presentation including successful treatment with Miltefosine
Post-kala-azar dermal leishmaniasis (PKDL) is a dermatologic manifestation that usually occurs after visceral leishmaniasis (VL) caused by Leishmania donovani. It is characterized by hypopigmented patches, a macular or maculopapular rash and nodular skin lesions on the body surface. Involvement of t...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
International Centre for Diarrhoeal Disease Research, Bangladesh
2013
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| Subjects: | |
| Online Access: | http://irep.iium.edu.my/87015/1/PKDL.pdf http://irep.iium.edu.my/87015/ http://doi.org/10.3329/jhpn.v31i2.16395 |
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| Summary: | Post-kala-azar dermal leishmaniasis (PKDL) is a dermatologic manifestation that usually occurs after visceral leishmaniasis (VL) caused by Leishmania donovani. It is characterized by hypopigmented patches, a macular or maculopapular rash and nodular skin lesions on the body surface. Involvement of the mucosae is very rare and unusual in PKDL. We report a case of PKDL that presented with polymorphic skin lesions,
along with involvement of peri-oral mucosa and tongue from an endemic area for kala-azar in Bangladesh. In the absence of a definite past history of kala- rapid serological tests against two recombinant (rK39 and rK28) leishmanial antigens, demonstration of Leishmania donovani (LD) body in the slit skin smear, and isolation of promastigotes by culture from a nodular lesion. The patient was treated with oral Miltefosine for three consecutive months and showed significant clinical improvement as demonstrated by a negative slit skin smear at two months after initiation of therapy. We report this case as an unusual presentation of mucosal involvement in PKDL and subsequent
treatment success with Miltefosine. |
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