Amebic liver abscess is associated with malnutrition and low serum leptin level
Background and Objective: Amebic liver abscess (ALA), the most common form of extra-intestinal amebiasis is caused by the protozoan parasite E. histolytica. It is a prevalent parasitic infection in the northern region of Bangladesh for which hospital admission is required. The aim of this investigat...
Saved in:
Main Authors: | , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
2016
|
Subjects: | |
Online Access: | http://irep.iium.edu.my/86938/1/ALA%20Leptin%20J%20Infect%20Dis%20Ther.pdf http://irep.iium.edu.my/86938/ http://doi.org/10.4172/2332-0877.1000298 |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
id |
my.iium.irep.86938 |
---|---|
record_format |
dspace |
spelling |
my.iium.irep.869382020-12-27T07:45:22Z http://irep.iium.edu.my/86938/ Amebic liver abscess is associated with malnutrition and low serum leptin level Alam, Faisal Salam, Md. Abdus Mahmood, Iftekhar Kabir, Mamun Chowdhury, Sharif Haque, Rashidul RA643 Public Health. Hygiene. Preventive Medicine - Communicable Diseases and Public Health Background and Objective: Amebic liver abscess (ALA), the most common form of extra-intestinal amebiasis is caused by the protozoan parasite E. histolytica. It is a prevalent parasitic infection in the northern region of Bangladesh for which hospital admission is required. The aim of this investigation was to explore the clinical spectrum of amebic liver abscess and its relationship with malnutrition and serum biomarker leptin. Methods: The study population included 90 hospitalized ALA patients and 90 healthy controls during the period of July 2012 to June 2015. Liver abscess was diagnosed initially by ultrasound imaging and amebic liver abscess was confirmed by detection of E. histolytica DNA in abscess aspirates using a Real Time PCR. Body Mass Index (BMI) was measured conventionally for nutritional status and serum leptin was estimated by ELISA. Results: Among the ALA cases (N=90), 37% had low BMI against only 3% of controls (N=90) [p<0.0001 at 95% CI]. About69 (76%) of low BMI patients had large or multiple liver abscess in comparison to 29% of standard BMI (p<0.0001 at 95% CI). Likewise, body fluid derangements such as edema, pleural effusion and ascites, either solitary or in combination were significantly higher (87% vs. 37%) among ALA with low BMI than standard BMI. Overwhelming majority of ALA patients 81(90%) was hypoleptinaemic. Conclusion: Malnutrition and low serum leptin are important associations in amebic liver abscess patients with significance in disease outcomes. 2016 Article PeerReviewed application/pdf en http://irep.iium.edu.my/86938/1/ALA%20Leptin%20J%20Infect%20Dis%20Ther.pdf Alam, Faisal and Salam, Md. Abdus and Mahmood, Iftekhar and Kabir, Mamun and Chowdhury, Sharif and Haque, Rashidul (2016) Amebic liver abscess is associated with malnutrition and low serum leptin level. Journal of Infectious Diseases & Therapy, 4 (5). pp. 1-4. ISSN 23320877 http://doi.org/10.4172/2332-0877.1000298 doi:10.4172/2332-0877.1000298 |
institution |
Universiti Islam Antarabangsa Malaysia |
building |
IIUM Library |
collection |
Institutional Repository |
continent |
Asia |
country |
Malaysia |
content_provider |
International Islamic University Malaysia |
content_source |
IIUM Repository (IREP) |
url_provider |
http://irep.iium.edu.my/ |
language |
English |
topic |
RA643 Public Health. Hygiene. Preventive Medicine - Communicable Diseases and Public Health |
spellingShingle |
RA643 Public Health. Hygiene. Preventive Medicine - Communicable Diseases and Public Health Alam, Faisal Salam, Md. Abdus Mahmood, Iftekhar Kabir, Mamun Chowdhury, Sharif Haque, Rashidul Amebic liver abscess is associated with malnutrition and low serum leptin level |
description |
Background and Objective: Amebic liver abscess (ALA), the most common form of extra-intestinal amebiasis is caused by the protozoan parasite E. histolytica. It is a prevalent parasitic infection in the northern region of Bangladesh for which hospital admission is required. The aim of this investigation was to explore the clinical spectrum of amebic liver abscess and its relationship with malnutrition and serum biomarker leptin.
Methods: The study population included 90 hospitalized ALA patients and 90 healthy controls during the period of July 2012 to June 2015. Liver abscess was diagnosed initially by ultrasound imaging and amebic liver abscess was confirmed by detection of E. histolytica DNA in abscess aspirates using a Real Time PCR. Body Mass Index (BMI) was measured conventionally for nutritional status and serum leptin was estimated by ELISA. Results: Among the ALA cases (N=90), 37% had low BMI against only 3% of controls (N=90) [p<0.0001 at 95% CI]. About69 (76%) of low BMI patients had large or multiple liver abscess in comparison to 29% of standard BMI (p<0.0001 at 95% CI). Likewise, body fluid derangements such as edema, pleural effusion and ascites, either solitary or in combination were significantly higher (87% vs. 37%) among ALA with low BMI than standard BMI. Overwhelming majority of ALA patients 81(90%) was hypoleptinaemic. Conclusion: Malnutrition and low serum leptin are important associations in amebic liver abscess patients with significance in disease outcomes. |
format |
Article |
author |
Alam, Faisal Salam, Md. Abdus Mahmood, Iftekhar Kabir, Mamun Chowdhury, Sharif Haque, Rashidul |
author_facet |
Alam, Faisal Salam, Md. Abdus Mahmood, Iftekhar Kabir, Mamun Chowdhury, Sharif Haque, Rashidul |
author_sort |
Alam, Faisal |
title |
Amebic liver abscess is associated with malnutrition and low serum leptin level |
title_short |
Amebic liver abscess is associated with malnutrition and low serum leptin level |
title_full |
Amebic liver abscess is associated with malnutrition and low serum leptin level |
title_fullStr |
Amebic liver abscess is associated with malnutrition and low serum leptin level |
title_full_unstemmed |
Amebic liver abscess is associated with malnutrition and low serum leptin level |
title_sort |
amebic liver abscess is associated with malnutrition and low serum leptin level |
publishDate |
2016 |
url |
http://irep.iium.edu.my/86938/1/ALA%20Leptin%20J%20Infect%20Dis%20Ther.pdf http://irep.iium.edu.my/86938/ http://doi.org/10.4172/2332-0877.1000298 |
_version_ |
1687393185976811520 |
score |
13.160551 |