Toll-like receptor-4 antagonist (D)-naltrexone protects against carbamyl- platelet activating factor (cPAF)-induced preterm labor in mice

• Main Authors: Wahid, Hanan Hamimi, Peck, Yin Chin, J.Sharkey, David, Diener, Kerrilyn R., Hutchinson, Mark R., Rice, Kenner C., Moldenhauer, Lachlan M., Robertson, Sarah A.
• Format: Article
• Language: English
• Published: Elsevier Inc. 2020
• Subjects: R Medicine (General); RB Pathology
• Online Access: http://irep.iium.edu.my/86640/1/My%20third%20PhD%20Publications.pdf; http://irep.iium.edu.my/86640/; https://doi.org/10.1016/j.ajpath.2020.01.008

Spontaneous preterm labor is frequently caused by an inflammatory response in the gestational tissues elicited by either infectious or sterile agents. In sterile preterm labor, the key regulators of inflammation are not identified, but platelet-activating factor (PAF) is implicated as a potential ra...